Systemic amyloidosis presenting with angina pectoris

Jassim Al Suwaidi, James L. Velianou, Morie Gertz, Richard O. Cannon, Stuart T. Higano, David Holmes, Amir Lerman

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Background: Manifestations of cardiac amyloidosis may include congestive heart failure and sudden cardiac death. Although vascular involvement in patients with amyloidosis is common, systemic amyloidosis presenting with angina is rare. Objectives: To report on patients with systemic amyloidosis presenting with angina pectoris. Design: Case series. Setting: Academic medical center. Patients: Five patients who presented with angina pectoris and normal coronary angiogram as the initial manifestation of systemic amyloidosis. Measurements: Endothelial-dependent and endothelial-independent coronary flow reserve. Results: All patients had coronary flow reserve abnormalities and subsequently developed congestive heart failure and systemic manifestations of amyloidosis. Histologic evaluation revealed amyloid deposition in the intramyocardial coronary vessels. Conclusions: Cardiac amyloidosis can present as angina pectoris associated with coronary flow reserve abnormalities despite normal coronary angiograms. This finding may have major therapeutic and prognostic implications in this patient population.

Original languageEnglish (US)
Pages (from-to)838-841
Number of pages4
JournalAnnals of Internal Medicine
Volume131
Issue number11
StatePublished - Dec 7 1999

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Angina Pectoris
Amyloidosis
Angiography
Heart Failure
Sudden Cardiac Death
Amyloid
Blood Vessels
Coronary Vessels
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Al Suwaidi, J., Velianou, J. L., Gertz, M., Cannon, R. O., Higano, S. T., Holmes, D., & Lerman, A. (1999). Systemic amyloidosis presenting with angina pectoris. Annals of Internal Medicine, 131(11), 838-841.

Systemic amyloidosis presenting with angina pectoris. / Al Suwaidi, Jassim; Velianou, James L.; Gertz, Morie; Cannon, Richard O.; Higano, Stuart T.; Holmes, David; Lerman, Amir.

In: Annals of Internal Medicine, Vol. 131, No. 11, 07.12.1999, p. 838-841.

Research output: Contribution to journalArticle

Al Suwaidi, J, Velianou, JL, Gertz, M, Cannon, RO, Higano, ST, Holmes, D & Lerman, A 1999, 'Systemic amyloidosis presenting with angina pectoris', Annals of Internal Medicine, vol. 131, no. 11, pp. 838-841.
Al Suwaidi J, Velianou JL, Gertz M, Cannon RO, Higano ST, Holmes D et al. Systemic amyloidosis presenting with angina pectoris. Annals of Internal Medicine. 1999 Dec 7;131(11):838-841.
Al Suwaidi, Jassim ; Velianou, James L. ; Gertz, Morie ; Cannon, Richard O. ; Higano, Stuart T. ; Holmes, David ; Lerman, Amir. / Systemic amyloidosis presenting with angina pectoris. In: Annals of Internal Medicine. 1999 ; Vol. 131, No. 11. pp. 838-841.
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