Systemic amyloidoses

Luis M. Blancas-Mejía, Marina Ramirez-Alvarado

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

The amyloidoses are a group of protein misfolding diseases in which the precursor protein undergoes a conformational change that triggers the formation of amyloid fibrils in different tissues and organs, causing cell death and organ failure. Amyloidoses can be either localized or systemic. In localized amyloidosis, amyloid deposits form at the site of precursor protein synthesis, whereas in systemic amyloidosis, amyloid deposition occurs distant from the site of precursor protein secretion. We review the type of proteins and cells involved and what is known about the complex pathophysiology of these diseases. We focus on light chain amyloidosis to illustrate how biochemical and biophysical studies have led to a deeper understanding of the pathogenesis of this devastating disease. We also review current cellular, tissue, and animal models and discuss the challenges and opportunities for future studies of the systemic amyloidoses.

Original languageEnglish (US)
Pages (from-to)745-774
Number of pages30
JournalAnnual Review of Biochemistry
Volume82
DOIs
StatePublished - Jun 2013

Fingerprint

Protein Precursors
Amyloidosis
Amyloid
Tissue
Cell death
Animals
Proteins
Deposits
Proteostasis Deficiencies
Amyloid Plaques
Cell Death
Animal Models
Light

Keywords

  • Amyloid fibril formation
  • Amyloid precursor proteins
  • Light chain amyloidosis
  • Protein aggregation
  • Protein misfolding
  • Transthyretin amyloidosis

ASJC Scopus subject areas

  • Biochemistry

Cite this

Systemic amyloidoses. / Blancas-Mejía, Luis M.; Ramirez-Alvarado, Marina.

In: Annual Review of Biochemistry, Vol. 82, 06.2013, p. 745-774.

Research output: Contribution to journalArticle

Blancas-Mejía, Luis M. ; Ramirez-Alvarado, Marina. / Systemic amyloidoses. In: Annual Review of Biochemistry. 2013 ; Vol. 82. pp. 745-774.
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