Systemic absorption of gallbladder sclerosing agents in the rabbit: A preliminary study

Kent B. Remley; Don A. Cubberley; Arthur S. Watanabe; James A. Nelson; Thomas V. Colby

doi:10.1097/00004424-198605000-00005

Systemic absorption of gallbladder sclerosing agents in the rabbit: A preliminary study

Kent B. Remley, Don A. Cubberley, Arthur S. Watanabe, James A. Nelson, Thomas V. Colby

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The absorbed levels of ethanol or tetracycline, used as gallbladder sclerosing agents, were measured in the systemic blood circulation of 16 rabbits. The maximal systemic level of ethanol was 46 μg/dl and of tetracycline was 4.6 μg/ml after 30 minutes of gallbladder exposure. Comparable serum levels would be considered nontoxic in humans. As a gallbladder sclerosing agent, tetracycline (50 mg/cc) was slightly more effective than 95% ethanol exposed for either 15 or 30 minutes.

Original language	English (US)
Pages (from-to)	396-399
Number of pages	4
Journal	Investigative radiology
Volume	21
Issue number	5
DOIs	https://doi.org/10.1097/00004424-198605000-00005
State	Published - May 1986

Keywords

Ethanol
Gallbladder ablation
Gallbladder sclerosis
Tetracycline
Toxicity

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1097/00004424-198605000-00005

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title = "Systemic absorption of gallbladder sclerosing agents in the rabbit: A preliminary study",

abstract = "The absorbed levels of ethanol or tetracycline, used as gallbladder sclerosing agents, were measured in the systemic blood circulation of 16 rabbits. The maximal systemic level of ethanol was 46 μg/dl and of tetracycline was 4.6 μg/ml after 30 minutes of gallbladder exposure. Comparable serum levels would be considered nontoxic in humans. As a gallbladder sclerosing agent, tetracycline (50 mg/cc) was slightly more effective than 95% ethanol exposed for either 15 or 30 minutes.",

keywords = "Ethanol, Gallbladder ablation, Gallbladder sclerosis, Tetracycline, Toxicity",

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T2 - A preliminary study

AU - Remley, Kent B.

AU - Cubberley, Don A.

AU - Watanabe, Arthur S.

AU - Nelson, James A.

AU - Colby, Thomas V.

PY - 1986/5

Y1 - 1986/5

N2 - The absorbed levels of ethanol or tetracycline, used as gallbladder sclerosing agents, were measured in the systemic blood circulation of 16 rabbits. The maximal systemic level of ethanol was 46 μg/dl and of tetracycline was 4.6 μg/ml after 30 minutes of gallbladder exposure. Comparable serum levels would be considered nontoxic in humans. As a gallbladder sclerosing agent, tetracycline (50 mg/cc) was slightly more effective than 95% ethanol exposed for either 15 or 30 minutes.

AB - The absorbed levels of ethanol or tetracycline, used as gallbladder sclerosing agents, were measured in the systemic blood circulation of 16 rabbits. The maximal systemic level of ethanol was 46 μg/dl and of tetracycline was 4.6 μg/ml after 30 minutes of gallbladder exposure. Comparable serum levels would be considered nontoxic in humans. As a gallbladder sclerosing agent, tetracycline (50 mg/cc) was slightly more effective than 95% ethanol exposed for either 15 or 30 minutes.

KW - Ethanol

KW - Gallbladder ablation

KW - Gallbladder sclerosis

KW - Tetracycline

KW - Toxicity

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Systemic absorption of gallbladder sclerosing agents in the rabbit: A preliminary study

Abstract

Keywords

ASJC Scopus subject areas

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