Systemic absorption of gallbladder sclerosing agents in the rabbit: A preliminary study

Kent B. Remley, Don A. Cubberley, Arthur S. Watanabe, James A. Nelson, Thomas V. Colby

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The absorbed levels of ethanol or tetracycline, used as gallbladder sclerosing agents, were measured in the systemic blood circulation of 16 rabbits. The maximal systemic level of ethanol was 46 μg/dl and of tetracycline was 4.6 μg/ml after 30 minutes of gallbladder exposure. Comparable serum levels would be considered nontoxic in humans. As a gallbladder sclerosing agent, tetracycline (50 mg/cc) was slightly more effective than 95% ethanol exposed for either 15 or 30 minutes.

Original languageEnglish (US)
Pages (from-to)396-399
Number of pages4
JournalInvestigative radiology
Volume21
Issue number5
DOIs
StatePublished - May 1986

Keywords

  • Ethanol
  • Gallbladder ablation
  • Gallbladder sclerosis
  • Tetracycline
  • Toxicity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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