System-independent ultrasound attenuation coefficient estimation using spectra normalization

Ultrasound attenuation coefficient estimation (ACE) has diagnostic potential for clinical applications such as differentiating tumors and quantifying fat content in the liver. The two commonly used ACE methods in the ultrasound array imaging system are the spectral shift method and the reference-phantom-based methods. The spectra shift method estimates the central frequency downshift along depth, whereas the reference-phantom-based methods use a well-calibrated phantom to cancel system dependent effects in attenuation estimation. In this study, we propose a novel system-independent ACE technique based on spectra normalization of different frequencies. This technique does not require a reference phantom for normalization. The power of each frequency component is normalized by the power of an adjacent frequency component in the spectrum to cancel system-dependent effects, such as focusing and time gain compensation (TGC). This method is referred to as the reference frequency method (RFM), and its performance has been evaluated in phantoms and in vivo liver studies. The RFM technique can be applied to various transducer geometries (e.g., linear or curved arrays) with different beam patterns (e.g., focused or unfocused).