Synthesis of (S)- and (R)-enantiomers of p-(4- hydroxybenzoyl)phenylalanine, useful photoaffinity labeling probes for peptide-protein binding sites

Abdul H. Fauq; Chewki Ziani-Cherif; Elliott Richelson

doi:10.1016/S0957-4166(98)00229-8

Synthesis of (S)- and (R)-enantiomers of p-(4- hydroxybenzoyl)phenylalanine, useful photoaffinity labeling probes for peptide-protein binding sites

Abdul H. Fauq, Chewki Ziani-Cherif, Elliott Richelson

Neuroscience

Research output: Contribution to journal › Article › peer-review

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Abstract

A high yield, multigram synthesis of both enantiomers of p-(4- hydroxybenzoyl)phenylalanine, cross-linking probes for peptide-protein binding interactions, is reported. The synthesis was accomplished using Schollkopf chiral auxiliary reagents.

Original language	English (US)
Pages (from-to)	2333-2338
Number of pages	6
Journal	Tetrahedron Asymmetry
Volume	9
Issue number	13
DOIs	https://doi.org/10.1016/S0957-4166(98)00229-8
State	Published - Jul 3 1998

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "Synthesis of (S)- and (R)-enantiomers of p-(4- hydroxybenzoyl)phenylalanine, useful photoaffinity labeling probes for peptide-protein binding sites",

abstract = "A high yield, multigram synthesis of both enantiomers of p-(4- hydroxybenzoyl)phenylalanine, cross-linking probes for peptide-protein binding interactions, is reported. The synthesis was accomplished using Schollkopf chiral auxiliary reagents.",

author = "Fauq, {Abdul H.} and Chewki Ziani-Cherif and Elliott Richelson",

note = "Funding Information: This work was supported by NIH (Grant no. MH27692, awarded to ER).",

year = "1998",

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doi = "10.1016/S0957-4166(98)00229-8",

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T1 - Synthesis of (S)- and (R)-enantiomers of p-(4- hydroxybenzoyl)phenylalanine, useful photoaffinity labeling probes for peptide-protein binding sites

AU - Fauq, Abdul H.

AU - Ziani-Cherif, Chewki

AU - Richelson, Elliott

N1 - Funding Information: This work was supported by NIH (Grant no. MH27692, awarded to ER).

PY - 1998/7/3

Y1 - 1998/7/3

N2 - A high yield, multigram synthesis of both enantiomers of p-(4- hydroxybenzoyl)phenylalanine, cross-linking probes for peptide-protein binding interactions, is reported. The synthesis was accomplished using Schollkopf chiral auxiliary reagents.

AB - A high yield, multigram synthesis of both enantiomers of p-(4- hydroxybenzoyl)phenylalanine, cross-linking probes for peptide-protein binding interactions, is reported. The synthesis was accomplished using Schollkopf chiral auxiliary reagents.

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U2 - 10.1016/S0957-4166(98)00229-8

DO - 10.1016/S0957-4166(98)00229-8

M3 - Article

AN - SCOPUS:0032479509

SN - 0957-4166

VL - 9

SP - 2333

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JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 13

ER -

Synthesis of (S)- and (R)-enantiomers of p-(4- hydroxybenzoyl)phenylalanine, useful photoaffinity labeling probes for peptide-protein binding sites

Abstract

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