Synthesis of (S)- and (R)-enantiomers of p-(4- hydroxybenzoyl)phenylalanine, useful photoaffinity labeling probes for peptide-protein binding sites

Abdul H. Fauq, Chewki Ziani-Cherif, Elliott Richelson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A high yield, multigram synthesis of both enantiomers of p-(4- hydroxybenzoyl)phenylalanine, cross-linking probes for peptide-protein binding interactions, is reported. The synthesis was accomplished using Schollkopf chiral auxiliary reagents.

Original languageEnglish (US)
Pages (from-to)2333-2338
Number of pages6
JournalTetrahedron Asymmetry
Volume9
Issue number13
DOIs
StatePublished - Jul 3 1998
Externally publishedYes

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phenylalanine
Enantiomers
enantiomers
Binding sites
Protein Binding
Labeling
Peptides
marking
peptides
Binding Sites
proteins
probes
synthesis
reagents
interactions
4-(4-hydroxybenzoyl)phenylalanine

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Synthesis of (S)- and (R)-enantiomers of p-(4- hydroxybenzoyl)phenylalanine, useful photoaffinity labeling probes for peptide-protein binding sites. / Fauq, Abdul H.; Ziani-Cherif, Chewki; Richelson, Elliott.

In: Tetrahedron Asymmetry, Vol. 9, No. 13, 03.07.1998, p. 2333-2338.

Research output: Contribution to journalArticle

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