Synthesis of racemic [2′‐13C]tryptophan

B. R. Branchini, F. G. Prendergast, G. A. Spencer, J. D. Hugdahl, B. D. Ray, M. D. Kemple

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

[2‐13C] Indole was synthesized in 39% yield by a three‐step procedure starting with K13CN. The labeled indole was converted to D,L[2′‐13C] tryptophan in three subsequent steps and the overall yield from K13CN was 13.5%. Proton and 13C‐NMR, and GC/mass spectral analyses confirmed the position and extent of 13C incorporation.

Original languageEnglish (US)
Pages (from-to)637-643
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume24
Issue number6
DOIs
StatePublished - Jun 1987

Keywords

  • D, L‐[2′‐C]tryptophan
  • [2‐C] indole
  • indole synthesis
  • tryptophan synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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    Branchini, B. R., Prendergast, F. G., Spencer, G. A., Hugdahl, J. D., Ray, B. D., & Kemple, M. D. (1987). Synthesis of racemic [2′‐13C]tryptophan. Journal of Labelled Compounds and Radiopharmaceuticals, 24(6), 637-643. https://doi.org/10.1002/jlcr.2580240605