Synthesis of macromolecular systems: Via lipase catalyzed biocatalytic reactions: Applications and future perspectives

Amit Kumar, Abdullah Khan, Shashwat Malhotra, Ravi Mosurkal, Ashish Dhawan, Mukesh K. Pandey, Brajendra K. Singh, Rajesh Kumar, Ashok K. Prasad, Sunil K. Sharma, Lynne A. Samuelson, Ashok L. Cholli, Christophe Len, Nigel G.J. Richards, Jayant Kumar, Rainer Haag, Arthur C. Watterson, Virinder S. Parmar

Research output: Contribution to journalReview article

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Abstract

Enzymes, being remarkable catalysts, are capable of accepting a wide range of complex molecules as substrates and catalyze a variety of reactions with a high degree of chemo-, stereo- and regioselectivity in most of the reactions. Biocatalysis can be used in both simple and complex chemical transformations without the need for tedious protection and deprotection chemistry that is very common in traditional organic synthesis. This current review highlights the applicability of one class of biocatalysts viz. "lipases" in synthetic transformations, the resolution of pharmaceutically important small molecules including polyphenols, amides, nucleosides and their precursors, the development of macromolecular systems (and their applications as drug/gene carriers), flame retardants, polymeric antioxidants and nanocrystalline solar cells, etc.

Original languageEnglish (US)
Pages (from-to)6855-6887
Number of pages33
JournalChemical Society Reviews
Volume45
Issue number24
DOIs
StatePublished - Dec 21 2016

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ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Kumar, A., Khan, A., Malhotra, S., Mosurkal, R., Dhawan, A., Pandey, M. K., Singh, B. K., Kumar, R., Prasad, A. K., Sharma, S. K., Samuelson, L. A., Cholli, A. L., Len, C., Richards, N. G. J., Kumar, J., Haag, R., Watterson, A. C., & Parmar, V. S. (2016). Synthesis of macromolecular systems: Via lipase catalyzed biocatalytic reactions: Applications and future perspectives. Chemical Society Reviews, 45(24), 6855-6887. https://doi.org/10.1039/c6cs00147e