Abstract
No‐carrier‐added (n.c.a) 14(R,S)‐[18F]fluoro‐6‐thia‐heptadecanoic acid (FTHA) has been synthesized for evaluation as a PET tracer for myocardial long chain fatty acid utilization. The n.c.a. nucleophilic radiofluorination of benzyl 14(R,S)‐tosyloxy‐6‐thia‐heptadecanoate in acetonitrile utilized (cryptate 2.2.2/K)2CO3 for anion activation. The resulting [18F]fluoro‐ester was quantitatively hydrolyzed with addition of aqueous KOH and the product purified by reversed phase HPLC. The radiochemical yield of purified FTHA was 35–65% (n=5) with a synthesis time of 50 min. Radiochemical purity was >99%.
Original language | English (US) |
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Pages (from-to) | 989-995 |
Number of pages | 7 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 29 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1991 |
Keywords
- F
- nucleophilic radiofluorination
- thia fatty acid
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry