Synthesis, material properties, and biocompatibility of a novel self-cross-linkable poly(caprolactone fumarate) as an injectable tissue engineering scaffold

Esmaiel Jabbari, Shanfeng Wang, Lichun Lu, James A. Gruetzmacher, Syed Ameenuddin, Theresa E. Hefferan, Bradford L. Currier, Anthony John Windebank, Michael J Yaszemski

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

A novel self-cross-linkable and biodegradable macromer, poly(caprolactone fumarate) (PCLF), has been developed for guided bone regeneration. This macromer is a copolymer of fumaryl chloride, which contains double bonds for in-situ cross-linking, and poly(ε-caprolactone), which has a flexible chain to facilitate self-cross-linkability. PCLF was characterized with Fourier transform infrared spectroscopy, 1H and 13C nuclear magnetic resonance spectroscopy, and gel permeation chromatography. Porous scaffolds were fabricated with sodium chloride particles as the porogen and a chemical initiation system. The PCLF scaffolds were characterized with scanning electron microscopy and micro-computed-tomography. The cytotoxicity and in vivo biocompatibility of PCLF were also assessed. Our results suggest that this novel copolymer, PCLF, is an injectable, self-cross-linkable, and biocompatible macromer that may be potentially used as a scaffold for tissue engineering applications.

Original languageEnglish (US)
Pages (from-to)2503-2511
Number of pages9
JournalBiomacromolecules
Volume6
Issue number5
DOIs
StatePublished - Sep 2005

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Tissue Scaffolds
Tissue Engineering
Scaffolds (biology)
Biocompatibility
Tissue engineering
Scaffolds
Materials properties
Copolymers
Injections
Gel permeation chromatography
Sodium chloride
Cytotoxicity
Nuclear magnetic resonance spectroscopy
Fourier transform infrared spectroscopy
Tomography
Bone
Scanning electron microscopy
Bone Regeneration
Fourier Transform Infrared Spectroscopy
Sodium Chloride

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Synthesis, material properties, and biocompatibility of a novel self-cross-linkable poly(caprolactone fumarate) as an injectable tissue engineering scaffold. / Jabbari, Esmaiel; Wang, Shanfeng; Lu, Lichun; Gruetzmacher, James A.; Ameenuddin, Syed; Hefferan, Theresa E.; Currier, Bradford L.; Windebank, Anthony John; Yaszemski, Michael J.

In: Biomacromolecules, Vol. 6, No. 5, 09.2005, p. 2503-2511.

Research output: Contribution to journalArticle

Jabbari, Esmaiel ; Wang, Shanfeng ; Lu, Lichun ; Gruetzmacher, James A. ; Ameenuddin, Syed ; Hefferan, Theresa E. ; Currier, Bradford L. ; Windebank, Anthony John ; Yaszemski, Michael J. / Synthesis, material properties, and biocompatibility of a novel self-cross-linkable poly(caprolactone fumarate) as an injectable tissue engineering scaffold. In: Biomacromolecules. 2005 ; Vol. 6, No. 5. pp. 2503-2511.
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