Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase
Lei Wang, Sita Kugel Desmoulin, Christina Cherian, Lisa Polin, Kathryn White, Juiwanna Kushner, Andreas Fulterer, Min Hwang Chang, Shermaine Mitchell-Ryan, Mark Stout, Michael F. Romero, Zhanjun Hou, Larry H. Matherly, Aleem Gangjee
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