Synthesis and immunostimulatory activity of substituted TLR7 agonists

Babatope Akinbobuyi; Lei Wang; Katherine C. Upchurch; Matthew R. Byrd; Charles A. Chang; Jeremy M. Quintana; Rachel E. Petersen; Zacharie J. Seifert; José R. Boquin; Sang Kon Oh; Robert R. Kane

doi:10.1016/j.bmcl.2016.07.049

Synthesis and immunostimulatory activity of substituted TLR7 agonists

Babatope Akinbobuyi, Lei Wang, Katherine C. Upchurch, Matthew R. Byrd, Charles A. Chang, Jeremy M. Quintana, Rachel E. Petersen, Zacharie J. Seifert, José R. Boquin, Sang Kon Oh, Robert R. Kane

Allergy, Asthma and Clinical Immunology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.

Original language	English (US)
Pages (from-to)	4246-4249
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	17
DOIs	https://doi.org/10.1016/j.bmcl.2016.07.049
State	Published - 2016

Keywords

Adenine derivatives
Immune activation
Toll-like receptor
Vaccines

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2016.07.049

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@article{a81b320aee53497d96e815d03b6ece26,

title = "Synthesis and immunostimulatory activity of substituted TLR7 agonists",

abstract = "Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.",

keywords = "Adenine derivatives, Immune activation, Toll-like receptor, Vaccines",

author = "Babatope Akinbobuyi and Lei Wang and Upchurch, {Katherine C.} and Byrd, {Matthew R.} and Chang, {Charles A.} and Quintana, {Jeremy M.} and Petersen, {Rachel E.} and Seifert, {Zacharie J.} and Boquin, {Jos{\'e} R.} and Oh, {Sang Kon} and Kane, {Robert R.}",

note = "Funding Information: This work was supported by funding from Baylor University (URC and URSA) and the Baylor Health Care System Foundation . Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2016",

doi = "10.1016/j.bmcl.2016.07.049",

language = "English (US)",

volume = "26",

pages = "4246--4249",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "17",

}

TY - JOUR

T1 - Synthesis and immunostimulatory activity of substituted TLR7 agonists

AU - Akinbobuyi, Babatope

AU - Wang, Lei

AU - Upchurch, Katherine C.

AU - Byrd, Matthew R.

AU - Chang, Charles A.

AU - Quintana, Jeremy M.

AU - Petersen, Rachel E.

AU - Seifert, Zacharie J.

AU - Boquin, José R.

AU - Oh, Sang Kon

AU - Kane, Robert R.

PY - 2016

Y1 - 2016

N2 - Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.

AB - Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.

KW - Adenine derivatives

KW - Immune activation

KW - Toll-like receptor

KW - Vaccines

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UR - http://www.scopus.com/inward/citedby.url?scp=84979771491&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2016.07.049

DO - 10.1016/j.bmcl.2016.07.049

M3 - Article

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AN - SCOPUS:84979771491

SN - 0960-894X

VL - 26

SP - 4246

EP - 4249

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 17

ER -

Synthesis and immunostimulatory activity of substituted TLR7 agonists

Abstract

Keywords

ASJC Scopus subject areas

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