Synthesis and biological activity of 3β-hydroxy-9,10-secopregna-5,7,10[19]-triene-20-one

A side chain analogue of vitamin D3

Martha Pass Murari, James M. Londowski, Susan Bollman, Rajiv Kumar

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The synthesis, biological and antagonistic activity of 3β-hydroxy-9,10-secopregna-5,7,10[19]-triene-20-one (20-oxopregnacalciferol, 7), a shortened side chain analogue of vitamin D3, are described. At the highest dose tested the analogue was found to have small though significant bone and soft tissue mobilization activity; no significant increase in intestinal calcium transport was noted. The compound was found to possess no antagonistic activity against vitamin D3.

Original languageEnglish (US)
Pages (from-to)615-619
Number of pages5
JournalJournal of Steroid Biochemistry
Volume17
Issue number6
DOIs
StatePublished - 1982

Fingerprint

Cholecalciferol
Bioactivity
Bone
Tissue
Calcium
Bone and Bones
20-oxopregnacalciferol

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Synthesis and biological activity of 3β-hydroxy-9,10-secopregna-5,7,10[19]-triene-20-one : A side chain analogue of vitamin D3. / Murari, Martha Pass; Londowski, James M.; Bollman, Susan; Kumar, Rajiv.

In: Journal of Steroid Biochemistry, Vol. 17, No. 6, 1982, p. 615-619.

Research output: Contribution to journalArticle

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