Synthesis and biological activity of 3β-hydroxy-9,10-secopregna-5,7,10[19]-triene-20-one: A side chain analogue of vitamin D3

Martha Pass Murari, James M. Londowski, Susan Bollman, Rajiv Kumar

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Abstract

The synthesis, biological and antagonistic activity of 3β-hydroxy-9,10-secopregna-5,7,10[19]-triene-20-one (20-oxopregnacalciferol, 7), a shortened side chain analogue of vitamin D3, are described. At the highest dose tested the analogue was found to have small though significant bone and soft tissue mobilization activity; no significant increase in intestinal calcium transport was noted. The compound was found to possess no antagonistic activity against vitamin D3.

Original languageEnglish (US)
Pages (from-to)615-619
Number of pages5
JournalJournal of Steroid Biochemistry
Volume17
Issue number6
DOIs
StatePublished - 1982

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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