TY - JOUR
T1 - Synthesis and biological activity of 3β-hydroxy-9,10-secopregna-5,7,10[19]-triene-20-one
T2 - A side chain analogue of vitamin D3
AU - Murari, Martha Pass
AU - Londowski, James M.
AU - Bollman, Susan
AU - Kumar, Rajiv
N1 - Funding Information:
Acktlowfrdyrmcnts-This research was supported by NIH grants AM 25409 and AM 26808 and a grant from the
PY - 1982/12
Y1 - 1982/12
N2 - The synthesis, biological and antagonistic activity of 3β-hydroxy-9,10-secopregna-5,7,10[19]-triene-20-one (20-oxopregnacalciferol, 7), a shortened side chain analogue of vitamin D3, are described. At the highest dose tested the analogue was found to have small though significant bone and soft tissue mobilization activity; no significant increase in intestinal calcium transport was noted. The compound was found to possess no antagonistic activity against vitamin D3.
AB - The synthesis, biological and antagonistic activity of 3β-hydroxy-9,10-secopregna-5,7,10[19]-triene-20-one (20-oxopregnacalciferol, 7), a shortened side chain analogue of vitamin D3, are described. At the highest dose tested the analogue was found to have small though significant bone and soft tissue mobilization activity; no significant increase in intestinal calcium transport was noted. The compound was found to possess no antagonistic activity against vitamin D3.
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U2 - 10.1016/0022-4731(82)90562-3
DO - 10.1016/0022-4731(82)90562-3
M3 - Article
C2 - 6294414
AN - SCOPUS:0020446543
SN - 0022-4731
VL - 17
SP - 615
EP - 619
JO - Journal of Steroid Biochemistry
JF - Journal of Steroid Biochemistry
IS - 6
ER -