Synthesis and biologic activity of 3β-thiovitamin D3

James M. Londowski, Larry K. Revelle, Susan Bollman Kost, Robert A. Corradino, Rajiv Kumar

Research output: Contribution to journalArticle

Abstract

We synthesized 3β-thiovitamin D3 from 7-dehydrocholesterol and tested its biological activity and protein binding properties. The thiovitamin was found to be a weak vitamin D agonist at high doses in vivo. It was poorly bound by both vitamin D-binding protein as well as by the intestinal cytosol receptor for 1,25-dihydroxyvitamin D. It did not increase the synthesis of calcium binding protein in the chick embryonic duodenum and did not block the activity of 1,25-dihydroxyvitamin D3 in this system We conclude that 3β -thiovitamin D3 is a weak vitamin D agonist in vivo with no agonist activity or antagonist activity to 1,25-dihydroxyvitamin D3 in the chick embryonic duodenum.

Original languageEnglish (US)
Pages (from-to)81-85
Number of pages5
JournalJournal of Steroid Biochemistry
Volume23
Issue number1
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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