Synthesis and 2D NMR analysis of a cyclopropane containing analogue of huperzine A

Alan P. Kozikowski; Fumio Yamada; Yuan Ping Pang

doi:10.1016/S0040-4039(00)79049-6

Synthesis and 2D NMR analysis of a cyclopropane containing analogue of huperzine A

Alan P. Kozikowski, Fumio Yamada, Yuan Ping Pang

Pharmacology

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8 Scopus citations

Abstract

In order to probe the possible binding site in acetylcholinesterase for huperzine A, a cyclopropane bearing analogue of huperzine A was synthesized, and the stereochemistry of this compound was established by NMR experiments.

Original language	English (US)
Pages (from-to)	2653-2656
Number of pages	4
Journal	Tetrahedron Letters
Volume	33
Issue number	19
DOIs	https://doi.org/10.1016/S0040-4039(00)79049-6
State	Published - May 5 1992

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)79049-6

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title = "Synthesis and 2D NMR analysis of a cyclopropane containing analogue of huperzine A",

abstract = "In order to probe the possible binding site in acetylcholinesterase for huperzine A, a cyclopropane bearing analogue of huperzine A was synthesized, and the stereochemistry of this compound was established by NMR experiments.",

author = "Kozikowski, {Alan P.} and Fumio Yamada and Pang, {Yuan Ping}",

note = "Funding Information: Acknowledgement. We are indebted to the National Institute on their support of our program.",

year = "1992",

month = may,

day = "5",

doi = "10.1016/S0040-4039(00)79049-6",

language = "English (US)",

volume = "33",

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journal = "Tetrahedron Letters",

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T1 - Synthesis and 2D NMR analysis of a cyclopropane containing analogue of huperzine A

AU - Kozikowski, Alan P.

AU - Yamada, Fumio

AU - Pang, Yuan Ping

N1 - Funding Information: Acknowledgement. We are indebted to the National Institute on their support of our program.

PY - 1992/5/5

Y1 - 1992/5/5

N2 - In order to probe the possible binding site in acetylcholinesterase for huperzine A, a cyclopropane bearing analogue of huperzine A was synthesized, and the stereochemistry of this compound was established by NMR experiments.

AB - In order to probe the possible binding site in acetylcholinesterase for huperzine A, a cyclopropane bearing analogue of huperzine A was synthesized, and the stereochemistry of this compound was established by NMR experiments.

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U2 - 10.1016/S0040-4039(00)79049-6

DO - 10.1016/S0040-4039(00)79049-6

M3 - Article

AN - SCOPUS:0026568403

SN - 0040-4039

VL - 33

SP - 2653

EP - 2656

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 19

ER -

Synthesis and 2D NMR analysis of a cyclopropane containing analogue of huperzine A

Abstract

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