TY - JOUR
T1 - Synovial sarcoma of the larynx and hypopharynx
AU - Dei Tos, Angelo P.
AU - Sciot, Raf
AU - Giannini, Caterina
AU - Furlanetto, Alberto
AU - Rinaldo, Alessandra
AU - Dal Cin, Paola
AU - Da Mosto, M. Cristina
AU - Ferlito, Alfio
PY - 1998
Y1 - 1998
N2 - Synovial sarcoma represents a mesenchymal malignancy of unknown histogenesis that most often occurs in the lower limbs of young adults. The head and neck region is a relatively rare location, in which the hypopharynx and larynx are, respectively, the most and least often affected anatomic sites. Histologically, synovial sarcomas are classified into monophasic and biphasic variants. Immunohistochemistry plays a major part in the differential diagnosis, enabling the demonstration of epithelial differentiation. Both monophasic and biphasic synovial sarcomas are characterized cytogenetically by the reciprocal translocation t(X; 18)(p 11.2;q 11.2) between chromosomes X and 18. Two cases of synovial sarcoma arising in the larynx and in the hypopharynx find in which cytogenetic analysis detected a diagnostic t(X; 18) chromosome aberration are reported here.
AB - Synovial sarcoma represents a mesenchymal malignancy of unknown histogenesis that most often occurs in the lower limbs of young adults. The head and neck region is a relatively rare location, in which the hypopharynx and larynx are, respectively, the most and least often affected anatomic sites. Histologically, synovial sarcomas are classified into monophasic and biphasic variants. Immunohistochemistry plays a major part in the differential diagnosis, enabling the demonstration of epithelial differentiation. Both monophasic and biphasic synovial sarcomas are characterized cytogenetically by the reciprocal translocation t(X; 18)(p 11.2;q 11.2) between chromosomes X and 18. Two cases of synovial sarcoma arising in the larynx and in the hypopharynx find in which cytogenetic analysis detected a diagnostic t(X; 18) chromosome aberration are reported here.
UR - http://www.scopus.com/inward/record.url?scp=7844220229&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7844220229&partnerID=8YFLogxK
U2 - 10.1177/000348949810701215
DO - 10.1177/000348949810701215
M3 - Article
C2 - 9865642
AN - SCOPUS:7844220229
SN - 0003-4894
VL - 107
SP - 1080
EP - 1085
JO - Annals of Otology, Rhinology and Laryngology
JF - Annals of Otology, Rhinology and Laryngology
IS - 12
ER -