Synergistic deleterious effects of nitrous oxide exposure and vitamin B12 deficiency

Patrick W. O'Leary; Michael J. Combs; Robert F. Schilling

Synergistic deleterious effects of nitrous oxide exposure and vitamin B₁₂ deficiency

Patrick W. O'Leary, Michael J. Combs, Robert F. Schilling

Pediatric and Adolescent Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Rats raised on a vitamin B₁₂-deficient or -sufficient diet were either exposed or not exposed to nitrous oxide for 3 hours before sacrifice. Bone marrow cells were assayed for thymidylate synthetase activity by the deoxyuridine suppression test. A synergistic interaction between vitamin B₁₂ deficiency and nitrous oxide exposure was observed.

Original language	English (US)
Pages (from-to)	422-427
Number of pages	6
Journal	The Journal of Laboratory and Clinical Medicine
Volume	105
Issue number	4
State	Published - Apr 1985

ASJC Scopus subject areas

Pathology and Forensic Medicine

Cite this

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title = "Synergistic deleterious effects of nitrous oxide exposure and vitamin B12 deficiency",

abstract = "Rats raised on a vitamin B12-deficient or -sufficient diet were either exposed or not exposed to nitrous oxide for 3 hours before sacrifice. Bone marrow cells were assayed for thymidylate synthetase activity by the deoxyuridine suppression test. A synergistic interaction between vitamin B12 deficiency and nitrous oxide exposure was observed.",

author = "O'Leary, {Patrick W.} and Combs, {Michael J.} and Schilling, {Robert F.}",

year = "1985",

month = apr,

language = "English (US)",

volume = "105",

pages = "422--427",

journal = "The Journal of Laboratory and Clinical Medicine",

issn = "0022-2143",

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T1 - Synergistic deleterious effects of nitrous oxide exposure and vitamin B12 deficiency

AU - O'Leary, Patrick W.

AU - Combs, Michael J.

AU - Schilling, Robert F.

PY - 1985/4

Y1 - 1985/4

N2 - Rats raised on a vitamin B12-deficient or -sufficient diet were either exposed or not exposed to nitrous oxide for 3 hours before sacrifice. Bone marrow cells were assayed for thymidylate synthetase activity by the deoxyuridine suppression test. A synergistic interaction between vitamin B12 deficiency and nitrous oxide exposure was observed.

AB - Rats raised on a vitamin B12-deficient or -sufficient diet were either exposed or not exposed to nitrous oxide for 3 hours before sacrifice. Bone marrow cells were assayed for thymidylate synthetase activity by the deoxyuridine suppression test. A synergistic interaction between vitamin B12 deficiency and nitrous oxide exposure was observed.

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M3 - Article

AN - SCOPUS:46549101764

SN - 0022-2143

VL - 105

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JO - The Journal of Laboratory and Clinical Medicine

JF - The Journal of Laboratory and Clinical Medicine

IS - 4

ER -

Synergistic deleterious effects of nitrous oxide exposure and vitamin B₁₂ deficiency

Abstract

ASJC Scopus subject areas

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