Synergistic deleterious effects of nitrous oxide exposure and vitamin B12 deficiency

P. W. O'Leary, M. J. Combs, R. F. Schilling

Research output: Contribution to journalArticlepeer-review

Abstract

Rats raised on a vitamin B12-deficient or -sufficient diet were either exposed or not exposed to nitrous oxide for 3 hours before sacrifice. Bone marrow cells were assayed for thymidylate synthetase activity by the deoxyuridine suppression test. A synergistic interaction between vitamin B12 deficiency and nitrous oxide exposure was observed.

Original languageEnglish (US)
Pages (from-to)428-431
Number of pages4
JournalJournal of Laboratory and Clinical Medicine
Volume105
Issue number4
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

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