Synergistic anti-Newcastle disease virus activity of pokeweed antiviral protein, ribavirin, and guanidine

Eric Weaver, Gary M. Aron

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Pokeweed antiviral protein (PAP), in combination with either guanidine or ribavirin, exhibited both synergy and antagonism toward the replication of Newcastle disease virus, low, medium, and high effective concentrations of both PAP and guanidine were synergistic when used in combination. High effective concentrations of ribavirin in combination with PAP were antagonistic, whereas low and medium effective concentrations were synergistic.

Original languageEnglish (US)
Pages (from-to)702-705
Number of pages4
JournalCanadian Journal of Microbiology
Volume44
Issue number7
DOIs
StatePublished - 1998
Externally publishedYes

Keywords

  • Guanidine
  • Newcastle disease virus
  • Pokeweed antiviral protein
  • Ribavirin
  • Synergy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Immunology
  • Microbiology

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