Syndecan-2

Jeffrey J. Essner, Eleanor Chen, Stephen C. Ekker

Research output: Contribution to journalShort surveypeer-review

75 Scopus citations

Abstract

The members of the Syndecan family of heparan sulfate proteoglycans play diverse roles in cell adhesion and cell communication by serving as co-receptors for both cell-signaling and extracellular matrix molecules. Syndecan-2 has been implicated in the formation of specialized membrane domains and functions as a direct link between the extracellular environment and the organization of the cortical cytoplasm. Recent studies have shown that syndecan-2 is required for angiogenesis, possibly by serving as a co-receptor for vascular endothelial growth factor, and cell-to-cell signaling during development of left-right asymmetry. This unique combination of activities suggests that syndecan-2 can function as a potential drug target for the development of multi-functional, anti-cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)152-156
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume38
Issue number2
DOIs
StatePublished - Feb 2006

Keywords

  • Angiogenesis
  • Cell adhesion
  • Cell signaling
  • Syndecan-2

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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