Syndecan-2

Jeffrey J. Essner, Eleanor Chen, Stephen C. Ekker

Research output: Contribution to journalShort survey

72 Scopus citations

Abstract

The members of the Syndecan family of heparan sulfate proteoglycans play diverse roles in cell adhesion and cell communication by serving as co-receptors for both cell-signaling and extracellular matrix molecules. Syndecan-2 has been implicated in the formation of specialized membrane domains and functions as a direct link between the extracellular environment and the organization of the cortical cytoplasm. Recent studies have shown that syndecan-2 is required for angiogenesis, possibly by serving as a co-receptor for vascular endothelial growth factor, and cell-to-cell signaling during development of left-right asymmetry. This unique combination of activities suggests that syndecan-2 can function as a potential drug target for the development of multi-functional, anti-cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)152-156
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume38
Issue number2
DOIs
StatePublished - Feb 2006

Keywords

  • Angiogenesis
  • Cell adhesion
  • Cell signaling
  • Syndecan-2

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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