Synchronous Rectal and Hepatic Resection of Rectal Metastatic Disease

Sarah York Boostrom, Liana Tsikitis Vassiliki, David M. Nagorney, Bruce G. Wolff, Heidi K. Chua, Scott Harmsen, David W. Larson

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Background: The objectives were to determine the feasibility of combined rectal and hepatic resections and analyze the disease-free survival and overall survival. Study Design: Sixty patients who underwent resection for metastatic rectal disease from 1991 to 2005 at Mayo Clinic were reviewed. Inclusion criteria were: rectal cancer with metastatic liver disease and resectability of metastases. The exclusion criteria were: metachronous resection (n = 15). Kaplan-Meier Survival estimated overall survival (OS) and disease-free survival (DFS). Cox proportional hazard models examined the association between groups and survival. Results: The cohort comprised 22 men and 23 women, with median age of 63 years. Surgical management included: abdominoperineal resection, 13 patients (29%); low anterior resection, 29 (64%); local excision, one; total proctocolectomy, one; and pelvic exenteration, one. Major hepatic resection was performed in 22%. There was no mortality, but there were 26 postoperative complications. Disease-free survival from local recurrence at 1, 2, and 5 years was 92%, 86%, and 80%, respectively. Disease-free survival from distant recurrence at 1, 2, and 5 years was 62%, 43%, and 28%, respectively. Overall survival at 1, 2 and 5 years was 88%, 72%, and 32%, respectively. Conclusions: Combined rectal and hepatic resection is safe. Morbidity and mortality do not preclude concurrent resection. The DFS and OS are comparable to that of patients undergoing a staged procedure.

Original languageEnglish (US)
Pages (from-to)1583-1588
Number of pages6
JournalJournal of Gastrointestinal Surgery
Volume15
Issue number9
DOIs
StatePublished - Sep 1 2011

Keywords

  • Hepatic
  • Metastatic
  • Rectal
  • Synchronous

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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    Boostrom, S. Y., Vassiliki, L. T., Nagorney, D. M., Wolff, B. G., Chua, H. K., Harmsen, S., & Larson, D. W. (2011). Synchronous Rectal and Hepatic Resection of Rectal Metastatic Disease. Journal of Gastrointestinal Surgery, 15(9), 1583-1588. https://doi.org/10.1007/s11605-011-1604-9