26 patients with active Hodgkin's disease during 26 pregnancies were evaluated at the Mayo Clinic between 1949 and 1989. One patient's mother and another patient's father had a previous history of Hodgkin's disease. The tumor diagnosis was established in the first, second, and third trimester in five, thirteen, and eight pregnancies. Three patients in the first trimester and two patients in the second trimester presented during relapse. The nodes were histologically classified as nodular sclerosing in 22, mixed cellularity in two, and lymphocyte predominant in two. The maternal stage of the Hodgkin's disease was as follows: three IA clinical, one IA pathological, nine IIA clinical, eight IIA pathological, four 11B clinical, and one 1VA clinical. Twelve patients were managed prior to 1970. Twenty-three fetuses were delivered without complication. Of these 23 babies, one twin died 48 hours after delivery and one was determined to have Down's syndrome. Two therapeutic abortions were performed. There was one degenerated fetus in a patient who presented with superior vena cava syndrome. In the first trimester, one patient was observed, one was treated with radiation therapy, one received Leukeran, and two had therapeutic abortions followed by radiation therapy. Two (40%) are alive and disease-free. In the second trimester, ten were treated with radiation therapy and three with other measures. Ten (80%) are alive and diseasefree. In the third trimester, five were treated with radiation, and three were observed. Five of eight patients (63%) are alive and disease-free. Twenty-one patients received further chemotherapy or radiation therapy at some point after delivery. Four of twelve (33%) patients managed prior to 1970 are alive and disease-free, and 13/14 (93%) patients managed after 1970 are alive and disease-free. The median follow-up for those who are alive and disease free is 16 years (9 years, 8 months to 40 years, 4 months).
|Original language||English (US)|
|Issue number||11 PART II|
|State||Published - 2000|
ASJC Scopus subject areas
- Cell Biology