Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women

Julio Licinio, André B. Negrão, Christos Mantzoros, Virginia Kaklamani, Ma Li Wong, Peter B. Bongiorno, Abeda Mulla, Laura Cearnal, Johannes D Veldhuis, Jeffrey S. Flier, Samuel M. Mccann, Philip W. Gold

Research output: Contribution to journalArticle

249 Citations (Scopus)

Abstract

Leptin, an adipocyte hormone, is a trophic factor for the reproductive system; however, it is still unknown whether there is a dynamic relation between fluctuations in circulating leptin and hypothalamic-pituitary- ovarian (HPO) axis hormones. To test the hypothesis that fluctuations in plasma leptin concentrations are related to the levels of luteinizing hormone (LH) and estradiol, we sampled plasma from six healthy women every 7 min for 24 h during days 8-11 of the menstrual cycle. Cross-correlation analysis throughout the 24-h cycle revealed a relation between release patterns of leptin and LH, with a lag of 42-84 min but no significant cross-correlation between LH and estradiol. The ultradian fluctuations in leptin levels showed pattern synchrony with those of both IH and estradiol as determined by cross- approximate entropy (cross-ApEn). At night, as leptin levels rose to their peak, the pulsatility profiles of LH changed significantly and became synchronous with those of leptin. LH pulses were fewer, of longer duration, higher amplitude, and larger area than during the day. Moreover, the synchronicity of LH and leptin occurred late at night, at which time estradiol and leptin also exhibited significantly stronger pattern coupling than during the day. We propose that leptin may regulate the minute-to- minute oscillations in the levels of LH and estradiol, and that the nocturnal rise in leptin may determine the change in nocturnal LH profile in the mid- to-late follicular phase that precedes ovulation. This may explain the disruption of hypothalamic-pituitary-ovarian function that is characteristic of states of low leptin release, such as anorexia nervosa and cachexia.

Original languageEnglish (US)
Pages (from-to)2541-2546
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number5
DOIs
StatePublished - Mar 3 1998
Externally publishedYes

Fingerprint

Luteinizing Hormone
Leptin
Estradiol
Hormones
Cachexia
Follicular Phase
Anorexia Nervosa
Entropy
Menstrual Cycle
Ovulation
Adipocytes

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. / Licinio, Julio; Negrão, André B.; Mantzoros, Christos; Kaklamani, Virginia; Wong, Ma Li; Bongiorno, Peter B.; Mulla, Abeda; Cearnal, Laura; Veldhuis, Johannes D; Flier, Jeffrey S.; Mccann, Samuel M.; Gold, Philip W.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 5, 03.03.1998, p. 2541-2546.

Research output: Contribution to journalArticle

Licinio, J, Negrão, AB, Mantzoros, C, Kaklamani, V, Wong, ML, Bongiorno, PB, Mulla, A, Cearnal, L, Veldhuis, JD, Flier, JS, Mccann, SM & Gold, PW 1998, 'Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women', Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 5, pp. 2541-2546. https://doi.org/10.1073/pnas.95.5.2541
Licinio, Julio ; Negrão, André B. ; Mantzoros, Christos ; Kaklamani, Virginia ; Wong, Ma Li ; Bongiorno, Peter B. ; Mulla, Abeda ; Cearnal, Laura ; Veldhuis, Johannes D ; Flier, Jeffrey S. ; Mccann, Samuel M. ; Gold, Philip W. / Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. In: Proceedings of the National Academy of Sciences of the United States of America. 1998 ; Vol. 95, No. 5. pp. 2541-2546.
@article{54bb435dc1e042a4b48424b019ebeb45,
title = "Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women",
abstract = "Leptin, an adipocyte hormone, is a trophic factor for the reproductive system; however, it is still unknown whether there is a dynamic relation between fluctuations in circulating leptin and hypothalamic-pituitary- ovarian (HPO) axis hormones. To test the hypothesis that fluctuations in plasma leptin concentrations are related to the levels of luteinizing hormone (LH) and estradiol, we sampled plasma from six healthy women every 7 min for 24 h during days 8-11 of the menstrual cycle. Cross-correlation analysis throughout the 24-h cycle revealed a relation between release patterns of leptin and LH, with a lag of 42-84 min but no significant cross-correlation between LH and estradiol. The ultradian fluctuations in leptin levels showed pattern synchrony with those of both IH and estradiol as determined by cross- approximate entropy (cross-ApEn). At night, as leptin levels rose to their peak, the pulsatility profiles of LH changed significantly and became synchronous with those of leptin. LH pulses were fewer, of longer duration, higher amplitude, and larger area than during the day. Moreover, the synchronicity of LH and leptin occurred late at night, at which time estradiol and leptin also exhibited significantly stronger pattern coupling than during the day. We propose that leptin may regulate the minute-to- minute oscillations in the levels of LH and estradiol, and that the nocturnal rise in leptin may determine the change in nocturnal LH profile in the mid- to-late follicular phase that precedes ovulation. This may explain the disruption of hypothalamic-pituitary-ovarian function that is characteristic of states of low leptin release, such as anorexia nervosa and cachexia.",
author = "Julio Licinio and Negr{\~a}o, {Andr{\'e} B.} and Christos Mantzoros and Virginia Kaklamani and Wong, {Ma Li} and Bongiorno, {Peter B.} and Abeda Mulla and Laura Cearnal and Veldhuis, {Johannes D} and Flier, {Jeffrey S.} and Mccann, {Samuel M.} and Gold, {Philip W.}",
year = "1998",
month = "3",
day = "3",
doi = "10.1073/pnas.95.5.2541",
language = "English (US)",
volume = "95",
pages = "2541--2546",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "5",

}

TY - JOUR

T1 - Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women

AU - Licinio, Julio

AU - Negrão, André B.

AU - Mantzoros, Christos

AU - Kaklamani, Virginia

AU - Wong, Ma Li

AU - Bongiorno, Peter B.

AU - Mulla, Abeda

AU - Cearnal, Laura

AU - Veldhuis, Johannes D

AU - Flier, Jeffrey S.

AU - Mccann, Samuel M.

AU - Gold, Philip W.

PY - 1998/3/3

Y1 - 1998/3/3

N2 - Leptin, an adipocyte hormone, is a trophic factor for the reproductive system; however, it is still unknown whether there is a dynamic relation between fluctuations in circulating leptin and hypothalamic-pituitary- ovarian (HPO) axis hormones. To test the hypothesis that fluctuations in plasma leptin concentrations are related to the levels of luteinizing hormone (LH) and estradiol, we sampled plasma from six healthy women every 7 min for 24 h during days 8-11 of the menstrual cycle. Cross-correlation analysis throughout the 24-h cycle revealed a relation between release patterns of leptin and LH, with a lag of 42-84 min but no significant cross-correlation between LH and estradiol. The ultradian fluctuations in leptin levels showed pattern synchrony with those of both IH and estradiol as determined by cross- approximate entropy (cross-ApEn). At night, as leptin levels rose to their peak, the pulsatility profiles of LH changed significantly and became synchronous with those of leptin. LH pulses were fewer, of longer duration, higher amplitude, and larger area than during the day. Moreover, the synchronicity of LH and leptin occurred late at night, at which time estradiol and leptin also exhibited significantly stronger pattern coupling than during the day. We propose that leptin may regulate the minute-to- minute oscillations in the levels of LH and estradiol, and that the nocturnal rise in leptin may determine the change in nocturnal LH profile in the mid- to-late follicular phase that precedes ovulation. This may explain the disruption of hypothalamic-pituitary-ovarian function that is characteristic of states of low leptin release, such as anorexia nervosa and cachexia.

AB - Leptin, an adipocyte hormone, is a trophic factor for the reproductive system; however, it is still unknown whether there is a dynamic relation between fluctuations in circulating leptin and hypothalamic-pituitary- ovarian (HPO) axis hormones. To test the hypothesis that fluctuations in plasma leptin concentrations are related to the levels of luteinizing hormone (LH) and estradiol, we sampled plasma from six healthy women every 7 min for 24 h during days 8-11 of the menstrual cycle. Cross-correlation analysis throughout the 24-h cycle revealed a relation between release patterns of leptin and LH, with a lag of 42-84 min but no significant cross-correlation between LH and estradiol. The ultradian fluctuations in leptin levels showed pattern synchrony with those of both IH and estradiol as determined by cross- approximate entropy (cross-ApEn). At night, as leptin levels rose to their peak, the pulsatility profiles of LH changed significantly and became synchronous with those of leptin. LH pulses were fewer, of longer duration, higher amplitude, and larger area than during the day. Moreover, the synchronicity of LH and leptin occurred late at night, at which time estradiol and leptin also exhibited significantly stronger pattern coupling than during the day. We propose that leptin may regulate the minute-to- minute oscillations in the levels of LH and estradiol, and that the nocturnal rise in leptin may determine the change in nocturnal LH profile in the mid- to-late follicular phase that precedes ovulation. This may explain the disruption of hypothalamic-pituitary-ovarian function that is characteristic of states of low leptin release, such as anorexia nervosa and cachexia.

UR - http://www.scopus.com/inward/record.url?scp=13144293061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13144293061&partnerID=8YFLogxK

U2 - 10.1073/pnas.95.5.2541

DO - 10.1073/pnas.95.5.2541

M3 - Article

C2 - 9482922

AN - SCOPUS:13144293061

VL - 95

SP - 2541

EP - 2546

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 5

ER -