Synaptic effects of antidepressants

Elliott Richelson

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Catecholamines, especially norepinephrine (NE) and serotonin (5-hydroxytryptamine [5-HT]), have been implicated in the pathophysiology of depression. However, their exact roles and their interrelationship are not completely understood. Antidepressants have various effects on the body, including action at the neuronal synapses of the brain; the two most important of these effects are blockade of the reuptake of neurotransmitters, including NE, 5-HT, and dopamine, and blockade of certain neurotransmitter receptors. Currently available antidepressants may be classified as inhibitors of monoamine oxidase or as blockers of biogenic amine neurotransmitter reuptake, the latter best describing tricyclic antidepressants and selective 5-HT-reuptake inhibitors, because they block the reuptake of one or more neurotransmitters. However, recently introduced antidepressants, such as the 5-HT-NE-reuptake inhibitors, have synaptic effects that differ from those of older compounds. These synaptic effects are important in explaining certain side effects and drug-drug interactions associated with all classes of antidepressants. This article reviews the synaptic effects of marketed antidepressant agents to elucidate the anticipated side effects and drug-interaction po-tential of these agents.

Original languageEnglish (US)
JournalJournal of Clinical Psychopharmacology
Volume16
Issue number3 SUPPL. 2
StatePublished - 1996

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Antidepressive Agents
Serotonin
Neurotransmitter Agents
Norepinephrine
Drug-Related Side Effects and Adverse Reactions
Drug Interactions
Neurotransmitter Receptor
Biogenic Amines
Monoamine Oxidase Inhibitors
Tricyclic Antidepressive Agents
Synapses
Catecholamines
Dopamine
Brain

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Synaptic effects of antidepressants. / Richelson, Elliott.

In: Journal of Clinical Psychopharmacology, Vol. 16, No. 3 SUPPL. 2, 1996.

Research output: Contribution to journalArticle

Richelson, E 1996, 'Synaptic effects of antidepressants', Journal of Clinical Psychopharmacology, vol. 16, no. 3 SUPPL. 2.
Richelson, Elliott. / Synaptic effects of antidepressants. In: Journal of Clinical Psychopharmacology. 1996 ; Vol. 16, No. 3 SUPPL. 2.
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