Abstract
Background & Aims It is not clear whether symptoms alone can be used to estimate the biologic activity of eosinophilic esophagitis (EoE). We aimed to evaluate whether symptoms can be used to identify patients with endoscopic and histologic features of remission. Methods Between April 2011 and June 2014, we performed a prospective, observational study and recruited 269 consecutive adults with EoE (67% male; median age, 39 years old) in Switzerland and the United States. Patients first completed the validated symptom-based EoE activity index patient-reported outcome instrument and then underwent esophagogastroduodenoscopy with esophageal biopsy collection. Endoscopic and histologic findings were evaluated with a validated grading system and standardized instrument, respectively. Clinical remission was defined as symptom score 2 in a high-power field (corresponds to approximately
| Original language | English (US) |
|---|---|
| Pages (from-to) | 581-590e4 |
| Journal | Gastroenterology |
| Volume | 150 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2016 |
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Keywords
- Disease Monitoring
- EEsAI
- Endoscopic Grading
- Remission
ASJC Scopus subject areas
- Gastroenterology
Cite this
Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults with Eosinophilic Esophagitis. / Safroneeva, Ekaterina; Straumann, Alex; Coslovsky, Michael; Zwahlen, Marcel; Kuehni, Claudia E.; Panczak, Radoslaw; Haas, Nadine A.; Alexander, Jeffrey A.; Dellon, Evan S.; Gonsalves, Nirmala; Hirano, Ikuo; Leung, John; Bussmann, Christian; Collins, Margaret H.; Newbury, Robert O.; De Petris, Giovanni; Smyrk, Thomas Christopher; Woosley, John T.; Yan, Pu; Yang, Guang Yu; Romero, Yvonne; Katzka, David A; Furuta, Glenn T.; Gupta, Sandeep K.; Aceves, Seema S.; Chehade, Mirna; Spergel, Jonathan M.; Schoepfer, Alain M.
In: Gastroenterology, Vol. 150, No. 3, 01.03.2016, p. 581-590e4.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults with Eosinophilic Esophagitis
AU - Safroneeva, Ekaterina
AU - Straumann, Alex
AU - Coslovsky, Michael
AU - Zwahlen, Marcel
AU - Kuehni, Claudia E.
AU - Panczak, Radoslaw
AU - Haas, Nadine A.
AU - Alexander, Jeffrey A.
AU - Dellon, Evan S.
AU - Gonsalves, Nirmala
AU - Hirano, Ikuo
AU - Leung, John
AU - Bussmann, Christian
AU - Collins, Margaret H.
AU - Newbury, Robert O.
AU - De Petris, Giovanni
AU - Smyrk, Thomas Christopher
AU - Woosley, John T.
AU - Yan, Pu
AU - Yang, Guang Yu
AU - Romero, Yvonne
AU - Katzka, David A
AU - Furuta, Glenn T.
AU - Gupta, Sandeep K.
AU - Aceves, Seema S.
AU - Chehade, Mirna
AU - Spergel, Jonathan M.
AU - Schoepfer, Alain M.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background & Aims It is not clear whether symptoms alone can be used to estimate the biologic activity of eosinophilic esophagitis (EoE). We aimed to evaluate whether symptoms can be used to identify patients with endoscopic and histologic features of remission. Methods Between April 2011 and June 2014, we performed a prospective, observational study and recruited 269 consecutive adults with EoE (67% male; median age, 39 years old) in Switzerland and the United States. Patients first completed the validated symptom-based EoE activity index patient-reported outcome instrument and then underwent esophagogastroduodenoscopy with esophageal biopsy collection. Endoscopic and histologic findings were evaluated with a validated grading system and standardized instrument, respectively. Clinical remission was defined as symptom score 2 in a high-power field (corresponds to approximately
AB - Background & Aims It is not clear whether symptoms alone can be used to estimate the biologic activity of eosinophilic esophagitis (EoE). We aimed to evaluate whether symptoms can be used to identify patients with endoscopic and histologic features of remission. Methods Between April 2011 and June 2014, we performed a prospective, observational study and recruited 269 consecutive adults with EoE (67% male; median age, 39 years old) in Switzerland and the United States. Patients first completed the validated symptom-based EoE activity index patient-reported outcome instrument and then underwent esophagogastroduodenoscopy with esophageal biopsy collection. Endoscopic and histologic findings were evaluated with a validated grading system and standardized instrument, respectively. Clinical remission was defined as symptom score 2 in a high-power field (corresponds to approximately
KW - Disease Monitoring
KW - EEsAI
KW - Endoscopic Grading
KW - Remission
UR - http://www.scopus.com/inward/record.url?scp=84959241734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959241734&partnerID=8YFLogxK
U2 - 10.1053/j.gastro.2015.11.004
DO - 10.1053/j.gastro.2015.11.004
M3 - Article
C2 - 26584601
AN - SCOPUS:84959241734
VL - 150
SP - 581-590e4
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 3
ER -