TY - JOUR
T1 - Symptoms
T2 - Aromatase inhibitor induced arthralgias
AU - Hershman, Dawn L.
AU - Loprinzi, Charles
AU - Schneider, Bryan P.
N1 - Publisher Copyright:
© Breast Cancer Research Foundation 2015
PY - 2015
Y1 - 2015
N2 - Recent clinical trials have demonstrated that aromatase inhibitors (AIs) are slightly more effective than tamoxifen at reducing breast cancer recurrences. However, breast cancer patients receiving AIs have a higher incidence of musculo-skeletal symptoms, particularly joint pain and stiffness. Musculoskeletal pain and stiffness can lead to noncompliance and increased utilization of health care resources. There is a suggestion that the syndrome is the result of estrogen deprivation and may share components with autoimmune diseases such as Sjögren’s syndrome. Several factors may increase the likelihood of developing AI arthralgia, such as prior chemotherapy, prior hormone replacement therapy, and increased weight; there are inconsistencies with regard to the data on genetic predispositions to this syndrome. While several studies have been done to evaluate interventions to treat or prevent AI arthral-gia, no clear treatment has emerged as being particularly benefi cial. Much of the research has been limited by small sample size, diffi culty blinding patients to placebo, inconsistent defi nitions of the syndrome, multiple patient reported outcomes, lack of objective outcome measures and heterogeneous patient populations. We are at the early stages of rese will ultimately improve the lives of women with breast cancer.
AB - Recent clinical trials have demonstrated that aromatase inhibitors (AIs) are slightly more effective than tamoxifen at reducing breast cancer recurrences. However, breast cancer patients receiving AIs have a higher incidence of musculo-skeletal symptoms, particularly joint pain and stiffness. Musculoskeletal pain and stiffness can lead to noncompliance and increased utilization of health care resources. There is a suggestion that the syndrome is the result of estrogen deprivation and may share components with autoimmune diseases such as Sjögren’s syndrome. Several factors may increase the likelihood of developing AI arthralgia, such as prior chemotherapy, prior hormone replacement therapy, and increased weight; there are inconsistencies with regard to the data on genetic predispositions to this syndrome. While several studies have been done to evaluate interventions to treat or prevent AI arthral-gia, no clear treatment has emerged as being particularly benefi cial. Much of the research has been limited by small sample size, diffi culty blinding patients to placebo, inconsistent defi nitions of the syndrome, multiple patient reported outcomes, lack of objective outcome measures and heterogeneous patient populations. We are at the early stages of rese will ultimately improve the lives of women with breast cancer.
KW - Aromatase inhibitors
KW - Arthralgias
KW - Breast cancer
UR - http://www.scopus.com/inward/record.url?scp=84931266021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931266021&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-16366-6_7
DO - 10.1007/978-3-319-16366-6_7
M3 - Article
C2 - 26059931
AN - SCOPUS:84931266021
SN - 0065-2598
VL - 862
SP - 89
EP - 100
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -