Abstract
Steroid cell tumor not otherwise specified (NOS) is a rare subtype of sex cord stromal tumor of the ovary and contributes less than 0.1% of all ovarian neoplasms. The majority of tumors occur in pre-menopausal women (mean age: 43 years), in which 56-77% of patients present with virilization due to excess testosterone. An 80-year-old woman with worsening alopecia and excessive growth of coarse hair on abdomen and genital area was found to have elevated serum testosterone level (462 ng/mL). Radiologic studies were consistent with bilateral adrenal adenomas. Bilateral adrenal venous sampling ruled out the adrenal gland as origin of hormone secretion. A diagnostic and therapeutic bilateral salpingooophorectomy confirmed steroid cell tumor NOS of the left ovary. Post-operatively, the patient had complete resolution of her symptoms and normalization of testosterone level. Our case emphasizes the importance of a clinical suspicion for an occult testosterone secreting ovarian tumor in a symptomatic patient without obvious ovarian mass on imaging.
Original language | English (US) |
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Article number | 6200 |
Pages (from-to) | 69-72 |
Number of pages | 4 |
Journal | Rare Tumors |
Volume | 8 |
Issue number | 2 |
DOIs | |
State | Published - Jun 29 2016 |
Keywords
- Adrenal venous sampling
- Steroid cell tumor not otherwise specified (NOS)
- Virilization
ASJC Scopus subject areas
- Histology
- Oncology