Symptomatic ovarian steroid cell tumor not otherwise specified in a post-menopausal woman

Neha Sood, Kaniksha Desai, Ana Maria Chindris, Jason Lewis, Tri A. Dinh

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Steroid cell tumor not otherwise specified (NOS) is a rare subtype of sex cord stromal tumor of the ovary and contributes less than 0.1% of all ovarian neoplasms. The majority of tumors occur in pre-menopausal women (mean age: 43 years), in which 56-77% of patients present with virilization due to excess testosterone. An 80-year-old woman with worsening alopecia and excessive growth of coarse hair on abdomen and genital area was found to have elevated serum testosterone level (462 ng/mL). Radiologic studies were consistent with bilateral adrenal adenomas. Bilateral adrenal venous sampling ruled out the adrenal gland as origin of hormone secretion. A diagnostic and therapeutic bilateral salpingooophorectomy confirmed steroid cell tumor NOS of the left ovary. Post-operatively, the patient had complete resolution of her symptoms and normalization of testosterone level. Our case emphasizes the importance of a clinical suspicion for an occult testosterone secreting ovarian tumor in a symptomatic patient without obvious ovarian mass on imaging.

Original languageEnglish (US)
Article number6200
Pages (from-to)69-72
Number of pages4
JournalRare Tumors
Volume8
Issue number2
DOIs
StatePublished - Jun 29 2016

Keywords

  • Adrenal venous sampling
  • Steroid cell tumor not otherwise specified (NOS)
  • Virilization

ASJC Scopus subject areas

  • Oncology
  • Histology

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    Sood, N., Desai, K., Chindris, A. M., Lewis, J., & Dinh, T. A. (2016). Symptomatic ovarian steroid cell tumor not otherwise specified in a post-menopausal woman. Rare Tumors, 8(2), 69-72. [6200]. https://doi.org/10.4081/rt.2016.6200