Symposium on epilepsy - Part V: Selection of antiepileptic drugs: A practical approach

J. W. Britton, E. L. So

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The selection of antiepileptic drugs (AEDs) is increasingly more complex as new agents become available. We discuss an individualized approach to selection of an AED that is tailored to each patient's need by considering the following six factors: effectiveness of the drug in controlling seizures, adverse effects profile, pharmacokinetic properties, special or unique patient situations, drug interactions, and cost of treatment. When these factors are considered, treatment complications and failure can be minimized by anticipating incompatibilities among drugs or between the drugs and the patient's condition. We emphasize the concept that the best AED therapy is dependent on optimal seizure control and absence of unacceptable side effects. In the current environment of medical practice, the cost of treatment has also become a major concern. With rare exceptions, no single factor dictates the choice of an AED. In the long term, the most cost- effective treatment will be the one that provides the most therapeutic benefit with the fewest complications and maximal patient satisfaction.

Original languageEnglish (US)
Pages (from-to)778-786
Number of pages9
JournalMayo Clinic Proceedings
Volume71
Issue number8
StatePublished - 1996

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Anticonvulsants
Epilepsy
Health Care Costs
Drug Incompatibility
Absence Epilepsy
Drug Costs
Treatment Failure
Patient Satisfaction
Drug Interactions
Pharmaceutical Preparations
Seizures
Pharmacokinetics
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Symposium on epilepsy - Part V : Selection of antiepileptic drugs: A practical approach. / Britton, J. W.; So, E. L.

In: Mayo Clinic Proceedings, Vol. 71, No. 8, 1996, p. 778-786.

Research output: Contribution to journalArticle

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