Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models

Kuichun Zhu, Hong Qin, Soung Chul Cha, Sattva S. Neelapu, Willem Overwijk, Gregory A. Lizee, James L. Abbruzzese, Patrick Hwu, Laszlo Radvanyi, Larry W. Kwak, David Z. Chang

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

We investigated the antitumor effect of survivin DNA vaccine in murine pancreatic and lymphoma models, and if xenogenic survivin can generate stronger immune response. We found that mice vaccinated with either human or mouse survivin DNA have significantly slower tumor growth and longer survival than those vaccinated with vector DNA. There was no significant difference between groups that received human and mouse survivin DNA. Lymphocyte infiltration was greater in tumors of mice immunized with survivin DNA than in tumors of control mice. We conclude that survivin DNA vaccine generated specific antitumor effects with increased lymphocyte infiltration at the tumor sites.

Original languageEnglish (US)
Pages (from-to)7955-7961
Number of pages7
JournalVaccine
Volume25
Issue number46
DOIs
StatePublished - Nov 14 2007

Keywords

  • DNA vaccine
  • Pancreatic carcinoma
  • Survivin

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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