Survival trends in glioblastoma and association with treating facility volume

Sonikpreet Aulakh, Michelle R. DeDeo, Joseph Free, Steven S. Rosenfeld, Alfredo Quinones-Hinojosa, Aneel Paulus, Alak Manna, Rami Manochakian, Asher A. Chanan-Khan, Sikander Ailawadhi

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Glioblastoma (GBM) is one of the most lethal cancers. Various prognostic factors impact the survival of GBM patients. To further understand this extremely poor prognosis disease, we evaluated the effect of the treatment facility volumes on overall survival (OS) over the years, especially after the approval of multimodality therapy using temozolomide (TMZ) in 2005. National Cancer Data Base (NCDB) was utilized to identify GBM cases from 2004 through 2013 using ICD-O-3 code 9440/3 to identify eligible patients. We focused on studying the association between treatment facility volume and OS after adjusting for the patient-, disease-, and facility-characteristics. A total of 60,672 eligible GBM patients with median age of 65 years, treated at 1166 facilities were included in this analysis. The median annual facility volume was 3 patients/year (range: 0.1–55.1) and median OS was 8.1 months. There was an improvement in OS across all facilities after 2005, when multimodality therapy with TMZ was approved. Treatment at quartile 4 centers (Q4; >7 patients/year) was independently associated with decreased all-cause mortality in a multivariate analysis (Q3 hazard ratio [HR]: 1.11, 95% CI 1.09, 1.13; Q2 HR: 1.15, 95% CI 1.12, 1.19; Q1 HR: 1.25, 95% CI 1.17, 1.33). Treatment facility volume independently affects OS among GBM patients. Factors that are variable in high- and low-volume centers should be addressed to mitigate outcome disparities.

Original languageEnglish (US)
Pages (from-to)271-274
Number of pages4
JournalJournal of Clinical Neuroscience
StatePublished - Oct 2019


  • Facility volume
  • Glioblastoma
  • Mortality
  • National cancer data base
  • Quartiles
  • Survival
  • Temozolomide

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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