Survival in young patients with intermediate/high-risk myelofibrosis: Estimates derived from databases for non transplant patients

Sergio Siragusa, Francesco Passamonti, Francisco Cervantes, Ayalew Tefferi

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Recent studies have suggested that allogenic stem cell transplantation (allo-SCT) might be a better treatment option, compared to drug therapy, for young patients with high-/intermediate-risk primary myelofibrosis (PMF). However, there are no controlled studies that validate this contention and allo-SCT is associated with a substantial risk of procedure-related mortality and morbidity. In a retrospective analysis of nontrans-plant PMF patients, who were both young (age <60 years) and with high-/intermediate-risk disease, 1- and 3-year survival estimates were 87% and 55%, 95% and 77%, 71% and 58%, respectively, involving patients seen at three different centers with expertise in PMF; these data did not appear to be inferior to those published in the context of either myeloablative or reduced-intensity conditioning allo-SCT. These observations underscore the need for controlled studies to accurately assess the value of allo-SCT in PMF.

Original languageEnglish (US)
Pages (from-to)140-143
Number of pages4
JournalAmerican journal of hematology
Issue number3
StatePublished - Mar 1 2009


ASJC Scopus subject areas

  • Hematology

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