Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MND

Keith A. Josephs; D. S. Knopman; J. L. Whitwell; B. F. Boeve; J. E. Parisi; R. C. Petersen; D. W. Dickson

doi:10.1212/01.wnl.0000173178.67986.7f

Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MND

Keith A. Josephs, D. S. Knopman, J. L. Whitwell, B. F. Boeve, J. E. Parisi, R. C. Petersen, D. W. Dickson

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.

Original language	English (US)
Pages (from-to)	645-647
Number of pages	3
Journal	Neurology
Volume	65
Issue number	4
DOIs	https://doi.org/10.1212/01.wnl.0000173178.67986.7f
State	Published - Aug 23 2005

ASJC Scopus subject areas

Clinical Neurology

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title = "Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MND",

abstract = "Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.",

author = "Josephs, {Keith A.} and Knopman, {D. S.} and Whitwell, {J. L.} and Boeve, {B. F.} and Parisi, {J. E.} and Petersen, {R. C.} and Dickson, {D. W.}",

note = "Funding Information: Supported by grants P50 AG16574 and U01 AG06786 from the National Institute on Aging, Bethesda, MD; and by the Robert H. and Clarice Smith and Abigail Van Buren AD Research Programs of the Mayo Foundation. ",

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T1 - Survival in two variants of tau-negative frontotemporal lobar degeneration

T2 - FTLD-U vs FTLD-MND

AU - Josephs, Keith A.

AU - Knopman, D. S.

AU - Whitwell, J. L.

AU - Boeve, B. F.

AU - Parisi, J. E.

AU - Petersen, R. C.

AU - Dickson, D. W.

N1 - Funding Information: Supported by grants P50 AG16574 and U01 AG06786 from the National Institute on Aging, Bethesda, MD; and by the Robert H. and Clarice Smith and Abigail Van Buren AD Research Programs of the Mayo Foundation.

PY - 2005/8/23

Y1 - 2005/8/23

N2 - Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.

AB - Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.

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Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MND

Abstract

ASJC Scopus subject areas

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