Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MND

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Abstract

Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.

Original languageEnglish (US)
Pages (from-to)645-647
Number of pages3
JournalNeurology
Volume65
Issue number4
DOIs
StatePublished - Aug 23 2005

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Frontotemporal Lobar Degeneration
Survival
Motor Neuron Disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MND",
abstract = "Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.",
author = "Josephs, {Keith Anthony} and Knopman, {David S} and Whitwell, {Jennifer Lynn} and Boeve, {Bradley F} and Parisi, {Joseph E} and Petersen, {Ronald Carl} and Dickson, {Dennis W}",
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T1 - Survival in two variants of tau-negative frontotemporal lobar degeneration

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AU - Knopman, David S

AU - Whitwell, Jennifer Lynn

AU - Boeve, Bradley F

AU - Parisi, Joseph E

AU - Petersen, Ronald Carl

AU - Dickson, Dennis W

PY - 2005/8/23

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N2 - Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.

AB - Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.

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