TY - JOUR
T1 - Survival in patients with primary systemic amyloidosis and raised serum cardiac troponins
AU - Dispenzieri, Angela
AU - Kyle, Robert A.
AU - Gertz, Morie A.
AU - Therneau, Terry M.
AU - Miller, Wayne L.
AU - Chandrasekaran, Krishnaswamy
AU - McConnell, Joseph P.
AU - Burritt, Mary F.
AU - Jaffe, Allan S.
N1 - Funding Information:
A Jaffe is a consultant for and receives research support from Dade and Roche Diagnostics, and has given talks sponsored by both companies. W Miller receives research support from Roche Diagnostics.
PY - 2003/5/24
Y1 - 2003/5/24
N2 - Patients with primary systemic amyloidosis that affects the heart have a poor outlook. Cardiac troponins T and I (cTnT, cTnI) are highly specific and sensitive biomarkers of myocardial injury. Values of these troponins provide quantitative information about the disease. We retrospectively assessed 261 patients newly diagnosed as having primary systemic amyloidosis. Median survival for patients with detectable cTnT and cTnI (6 and 8 months, respectively), was worse than that for those with undetectable values (22 and 21 months, respectively). Median and 25th and 75th percentile values for cTnT were 0.024 μg/L, less than 0.01 μg/L, and 0.084 μg/L, and for cTnI were 0.1 μg/L, 0.05 μg/L, and 0.24 μg/L, respectively. After multivariate analysis, cTnT proved a better predictor of survival than cTnI.
AB - Patients with primary systemic amyloidosis that affects the heart have a poor outlook. Cardiac troponins T and I (cTnT, cTnI) are highly specific and sensitive biomarkers of myocardial injury. Values of these troponins provide quantitative information about the disease. We retrospectively assessed 261 patients newly diagnosed as having primary systemic amyloidosis. Median survival for patients with detectable cTnT and cTnI (6 and 8 months, respectively), was worse than that for those with undetectable values (22 and 21 months, respectively). Median and 25th and 75th percentile values for cTnT were 0.024 μg/L, less than 0.01 μg/L, and 0.084 μg/L, and for cTnI were 0.1 μg/L, 0.05 μg/L, and 0.24 μg/L, respectively. After multivariate analysis, cTnT proved a better predictor of survival than cTnI.
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U2 - 10.1016/S0140-6736(03)13396-X
DO - 10.1016/S0140-6736(03)13396-X
M3 - Article
C2 - 12781539
AN - SCOPUS:0038778403
SN - 0140-6736
VL - 361
SP - 1787
EP - 1789
JO - The Lancet
JF - The Lancet
IS - 9371
ER -