Survival following synchronous colon cancer resection

Cornelius A. Thiels, Nimesh D. Naik, John R. Bergquist, Blake A. Spindler, Elizabeth B Habermann, Scott R. Kelley, Bruce G. Wolff, Kellie L. Mathis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Synchronous colon cancers, defined as two or more primary colon cancer detected simultaneously at the time of initial diagnosis, account for up to 5% of all colon cancer diagnoses. Management principles and outcomes remain largely undefined. Methods: A retrospective institutional review of patients undergoing curative intent resection for colon adenocarcinoma (Stages I–III) from 1995 to 2007 was performed. Hereditary causes or inflammatory bowel disease were excluded. Matching was performed and Kaplan–Meier analysis was used to compare overall survival. Results: Of 2,387 patients, 100 (4.2%) had synchronous cancers. Patients with synchronous lesions tended to be older (median 77 vs. 72 years, P <0.001) with more advanced tumors (41.0% vs. 31.4% Stage III, P = 0.04). After matching, there were no differences in demographics or tumor factors (all P > 0.05). Compared to solitary, synchronous cancers demonstrated an inferior 10-year overall survival (53.9% vs. 36.5%, P = 0.009). Subset analysis of patients with synchronous cancers showed no difference in overall survival between those with extended versus segmental resections at 120-months (P = 0.07). Conclusion: Synchronous colon cancer is associated with decreased overall survival compared to patients with solitary tumors. Extended resection does not confer a survival benefit in these patients. Further research is needed to determine how to mitigate the poor outcomes. J. Surg. Oncol. 2016;114:80–85.

Original languageEnglish (US)
Pages (from-to)80-85
Number of pages6
JournalJournal of Surgical Oncology
Volume114
Issue number1
DOIs
StatePublished - Jul 1 2016

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Colonic Neoplasms
Survival
Neoplasms
Inflammatory Bowel Diseases
Colon
Adenocarcinoma
Research

Keywords

  • colon cancer
  • MSI
  • solitary lesions
  • synchronous

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Thiels, C. A., Naik, N. D., Bergquist, J. R., Spindler, B. A., Habermann, E. B., Kelley, S. R., ... Mathis, K. L. (2016). Survival following synchronous colon cancer resection. Journal of Surgical Oncology, 114(1), 80-85. https://doi.org/10.1002/jso.24258

Survival following synchronous colon cancer resection. / Thiels, Cornelius A.; Naik, Nimesh D.; Bergquist, John R.; Spindler, Blake A.; Habermann, Elizabeth B; Kelley, Scott R.; Wolff, Bruce G.; Mathis, Kellie L.

In: Journal of Surgical Oncology, Vol. 114, No. 1, 01.07.2016, p. 80-85.

Research output: Contribution to journalArticle

Thiels, CA, Naik, ND, Bergquist, JR, Spindler, BA, Habermann, EB, Kelley, SR, Wolff, BG & Mathis, KL 2016, 'Survival following synchronous colon cancer resection', Journal of Surgical Oncology, vol. 114, no. 1, pp. 80-85. https://doi.org/10.1002/jso.24258
Thiels CA, Naik ND, Bergquist JR, Spindler BA, Habermann EB, Kelley SR et al. Survival following synchronous colon cancer resection. Journal of Surgical Oncology. 2016 Jul 1;114(1):80-85. https://doi.org/10.1002/jso.24258
Thiels, Cornelius A. ; Naik, Nimesh D. ; Bergquist, John R. ; Spindler, Blake A. ; Habermann, Elizabeth B ; Kelley, Scott R. ; Wolff, Bruce G. ; Mathis, Kellie L. / Survival following synchronous colon cancer resection. In: Journal of Surgical Oncology. 2016 ; Vol. 114, No. 1. pp. 80-85.
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AB - Background: Synchronous colon cancers, defined as two or more primary colon cancer detected simultaneously at the time of initial diagnosis, account for up to 5% of all colon cancer diagnoses. Management principles and outcomes remain largely undefined. Methods: A retrospective institutional review of patients undergoing curative intent resection for colon adenocarcinoma (Stages I–III) from 1995 to 2007 was performed. Hereditary causes or inflammatory bowel disease were excluded. Matching was performed and Kaplan–Meier analysis was used to compare overall survival. Results: Of 2,387 patients, 100 (4.2%) had synchronous cancers. Patients with synchronous lesions tended to be older (median 77 vs. 72 years, P <0.001) with more advanced tumors (41.0% vs. 31.4% Stage III, P = 0.04). After matching, there were no differences in demographics or tumor factors (all P > 0.05). Compared to solitary, synchronous cancers demonstrated an inferior 10-year overall survival (53.9% vs. 36.5%, P = 0.009). Subset analysis of patients with synchronous cancers showed no difference in overall survival between those with extended versus segmental resections at 120-months (P = 0.07). Conclusion: Synchronous colon cancer is associated with decreased overall survival compared to patients with solitary tumors. Extended resection does not confer a survival benefit in these patients. Further research is needed to determine how to mitigate the poor outcomes. J. Surg. Oncol. 2016;114:80–85.

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