Survival and recurrence in nonmycosis fungoides primary cutaneous lymphoma

Jonathan D. Tward, Charles V. Cachoeira, Mohammed E. Salama, Robert J. Lee, Glen Bowen, Sherrie L. Perkins, Martha Glenn, Michael Confer, David K. Gaffney

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate overall and relapse-free survival (RFS) in patients with nonmycosis fungoides (non-MF) primary cutaneous lymphoma (PCL). Methods: Thirty-eight patients with PCL excluding cases of MF treated between 1993 and 2006 were analyzed retrospectively. Survival statistics were estimated by the methods of Kaplan and Meier, and univariate and multivariate significance testing were performed by Cox regression analysis. Results: The median follow-up was 34.6 months (range, 2-138.3 months). The overall survival for the entire study population, at 5 and 10 years, was 97% and 78%, respectively. The RFS for the entire study population, at 5 and 10 years, was 30% and 22%, respectively. For those who received radiotherapy (RT) as a component of their initial therapy, the RFS at 5 and 10 years was 48% and 36%, respectively. Among those receiving RT who relapsed, the site of relapse was out-of-field in 82% of the cases. In our multivariate analysis, only RT as a component of the initial therapy and the absence of bulky disease had a statistically significant improvement in RFS (P = 0.01 and <0.01, respectively). Conclusion: RT improves the local control and RFS of patients with non-MF PCL.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalCancer Journal
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2009

Keywords

  • Nonmycosis fungoides primary cutaneous lymphoma
  • Radiotherapy
  • Relapse-free survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Tward, J. D., Cachoeira, C. V., Salama, M. E., Lee, R. J., Bowen, G., Perkins, S. L., Glenn, M., Confer, M., & Gaffney, D. K. (2009). Survival and recurrence in nonmycosis fungoides primary cutaneous lymphoma. Cancer Journal, 15(1), 87-92. https://doi.org/10.1097/PPO.0b013e318197684e