Abstract
Occlusive PVT concurrent with chronic liver disease is a common clinical entity among pediatric patients referred for transplantation. The natural history of PVT is unknown. Our aim was to determine, using a retrospective cohort design, if children under 13 yr with chronic liver disease and concomitant PVT have an increased mortality risk prior to and after transplantation. A total of 203 patients were included in the study. Nearly 10% of the population had PVT (n = 19); 63.2% of PVT patients (5.9% of total cohort) underwent liver transplantation (n = 12). PVT patients tended to be younger than non-PVT patients at evaluation (1.94 ± 3.51 vs. 3.79 ± 4.11, p = 0.059). Clinical and demographic factors were similar between the two groups. Regarding survival, four PVT patients died, of which two had undergone transplantation. Kaplan-Meier analyses indicated that PVT and non-PVT patients had similar survival from the time of evaluation, on the waiting list, and after transplant. Although limited by sample size, our study suggests that a diagnosis of PVT does not increase the mortality risk for children waiting for a liver transplant. Further study is needed to discern variations in mortality risk that may occur in the pediatric chronic liver disease population with PVT.
Original language | English (US) |
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Pages (from-to) | 132-137 |
Number of pages | 6 |
Journal | Pediatric Transplantation |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2010 |
Keywords
- End-stage liver disease
- Mortality
- Pediatric end-stage liver disease
- Pediatric liver transplantation
- Portal vein thrombosis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Transplantation