Survival among children with portal vein thrombosis and end-stage liver disease

Shaza Al-Holou, Amit Mathur, David Ranney, James Kubus, Michael J. Englesbe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Occlusive PVT concurrent with chronic liver disease is a common clinical entity among pediatric patients referred for transplantation. The natural history of PVT is unknown. Our aim was to determine, using a retrospective cohort design, if children under 13 yr with chronic liver disease and concomitant PVT have an increased mortality risk prior to and after transplantation. A total of 203 patients were included in the study. Nearly 10% of the population had PVT (n = 19); 63.2% of PVT patients (5.9% of total cohort) underwent liver transplantation (n = 12). PVT patients tended to be younger than non-PVT patients at evaluation (1.94 ± 3.51 vs. 3.79 ± 4.11, p = 0.059). Clinical and demographic factors were similar between the two groups. Regarding survival, four PVT patients died, of which two had undergone transplantation. Kaplan-Meier analyses indicated that PVT and non-PVT patients had similar survival from the time of evaluation, on the waiting list, and after transplant. Although limited by sample size, our study suggests that a diagnosis of PVT does not increase the mortality risk for children waiting for a liver transplant. Further study is needed to discern variations in mortality risk that may occur in the pediatric chronic liver disease population with PVT.

Original languageEnglish (US)
Pages (from-to)132-137
Number of pages6
JournalPediatric Transplantation
Volume14
Issue number1
DOIs
StatePublished - Feb 2010
Externally publishedYes

Fingerprint

End Stage Liver Disease
Portal Vein
Thrombosis
Survival
Liver Diseases
Chronic Disease
Transplantation
Pediatrics
Transplants
Child Mortality
Waiting Lists
Mortality
Kaplan-Meier Estimate
Natural History
Liver Transplantation
Sample Size
Population
Demography
Liver

Keywords

  • End-stage liver disease
  • Mortality
  • Pediatric end-stage liver disease
  • Pediatric liver transplantation
  • Portal vein thrombosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Survival among children with portal vein thrombosis and end-stage liver disease. / Al-Holou, Shaza; Mathur, Amit; Ranney, David; Kubus, James; Englesbe, Michael J.

In: Pediatric Transplantation, Vol. 14, No. 1, 02.2010, p. 132-137.

Research output: Contribution to journalArticle

Al-Holou, Shaza ; Mathur, Amit ; Ranney, David ; Kubus, James ; Englesbe, Michael J. / Survival among children with portal vein thrombosis and end-stage liver disease. In: Pediatric Transplantation. 2010 ; Vol. 14, No. 1. pp. 132-137.
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