Survival after inflammatory bowel disease-associated colorectal cancer in the colon cancer family registry

Scott V. Adams, Dennis J. Ahnen, John A. Baron, Peter T. Campbell, Steven Gallinger, William M. Grady, Loic Lemarchand, Noralane Morey Lindor, John D. Potter, Polly A. Newcomb

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm selfreport of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non- IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputatissociated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR =1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR =1.36; 95%CI:1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC.

Original languageEnglish (US)
Pages (from-to)3241-3248
Number of pages8
JournalWorld Journal of Gastroenterology
Volume19
Issue number21
DOIs
StatePublished - Jun 7 2013

Fingerprint

Inflammatory Bowel Diseases
Colonic Neoplasms
Registries
Colorectal Neoplasms
Survival
Medical Records
Self Report
Endoscopy

Keywords

  • Cancer survival
  • Colorectal cancer
  • Inflammation
  • Inflammatory bowel disease
  • Outcomes research

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Adams, S. V., Ahnen, D. J., Baron, J. A., Campbell, P. T., Gallinger, S., Grady, W. M., ... Newcomb, P. A. (2013). Survival after inflammatory bowel disease-associated colorectal cancer in the colon cancer family registry. World Journal of Gastroenterology, 19(21), 3241-3248. https://doi.org/10.3748/wjg.v19.i21.3241

Survival after inflammatory bowel disease-associated colorectal cancer in the colon cancer family registry. / Adams, Scott V.; Ahnen, Dennis J.; Baron, John A.; Campbell, Peter T.; Gallinger, Steven; Grady, William M.; Lemarchand, Loic; Lindor, Noralane Morey; Potter, John D.; Newcomb, Polly A.

In: World Journal of Gastroenterology, Vol. 19, No. 21, 07.06.2013, p. 3241-3248.

Research output: Contribution to journalArticle

Adams, SV, Ahnen, DJ, Baron, JA, Campbell, PT, Gallinger, S, Grady, WM, Lemarchand, L, Lindor, NM, Potter, JD & Newcomb, PA 2013, 'Survival after inflammatory bowel disease-associated colorectal cancer in the colon cancer family registry', World Journal of Gastroenterology, vol. 19, no. 21, pp. 3241-3248. https://doi.org/10.3748/wjg.v19.i21.3241
Adams, Scott V. ; Ahnen, Dennis J. ; Baron, John A. ; Campbell, Peter T. ; Gallinger, Steven ; Grady, William M. ; Lemarchand, Loic ; Lindor, Noralane Morey ; Potter, John D. ; Newcomb, Polly A. / Survival after inflammatory bowel disease-associated colorectal cancer in the colon cancer family registry. In: World Journal of Gastroenterology. 2013 ; Vol. 19, No. 21. pp. 3241-3248.
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abstract = "AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm selfreport of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95{\%}CI of mortality, comparing IBD-associated to non- IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputatissociated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR =1.08; 95{\%}CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR =1.36; 95{\%}CI:1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC.",
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