Surgical treatment and outcomes of patients with extramammary paget disease

A cohort study

Sharon J. Kim, Agnieszka K. Thompson, Adeel S. Zubair, Clark C. Otley, Christopher J. Arpey, Christian Baum, Randall K. Roenigk, Christine M. Lohse, Jerry D. Brewer

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

BACKGROUND Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma occurring mainly in the anogenital region. Traditional management with wide local excision has shown high recurrence rates, thus Mohs micrographic surgery (MMS) has emerged as a promising treatment option. OBJECTIVE To compare long-term outcomes after treatment with MMS or excision for primary EMPD. METHODS AND MATERIALS Retrospective cohort review was conducted for 207 patients with EMPD treated at Mayo Clinic in Rochester, MN, between 1961 and 2012. RESULTS Of the 25 patients treated with MMS, 19 primary tumors were included for outcome analysis, with an estimated 5-year recurrence-free survival rate of 91% (95% confidence interval [CI], 75-100) using Kaplan-Meier curve analysis. Of 158 patients treated with local excision, 124 were included for the analysis, with an estimated 5-year recurrence-free survival rate of 66% (95% CI, 56-78). The hazard ratio (HR) for association of treatment was 0.4 (95% CI, 0.10-1.65; p = .20). Estimated 5-year overall survival rates were 79% for MMS (95% CI, 61-100) and 68% for excision (95% CI, 59-78) (HR, 1.39 [95% CI, 0.69-2.82]; p = .36). CONCLUSION Although treatment of primary EMPD with MMS versus excision did not show statistical difference, MMS demonstrated favorable long-term outcomes and was associated with a higher recurrencefree survival rate.

Original languageEnglish (US)
Pages (from-to)708-714
Number of pages7
JournalDermatologic Surgery
Volume43
Issue number5
DOIs
StatePublished - 2017

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Extramammary Paget's Disease
Mohs Surgery
Cohort Studies
Confidence Intervals
Survival Rate
Recurrence
Kaplan-Meier Estimate
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

Kim, S. J., Thompson, A. K., Zubair, A. S., Otley, C. C., Arpey, C. J., Baum, C., ... Brewer, J. D. (2017). Surgical treatment and outcomes of patients with extramammary paget disease: A cohort study. Dermatologic Surgery, 43(5), 708-714. https://doi.org/10.1097/DSS.0000000000001051

Surgical treatment and outcomes of patients with extramammary paget disease : A cohort study. / Kim, Sharon J.; Thompson, Agnieszka K.; Zubair, Adeel S.; Otley, Clark C.; Arpey, Christopher J.; Baum, Christian; Roenigk, Randall K.; Lohse, Christine M.; Brewer, Jerry D.

In: Dermatologic Surgery, Vol. 43, No. 5, 2017, p. 708-714.

Research output: Contribution to journalReview article

Kim, SJ, Thompson, AK, Zubair, AS, Otley, CC, Arpey, CJ, Baum, C, Roenigk, RK, Lohse, CM & Brewer, JD 2017, 'Surgical treatment and outcomes of patients with extramammary paget disease: A cohort study', Dermatologic Surgery, vol. 43, no. 5, pp. 708-714. https://doi.org/10.1097/DSS.0000000000001051
Kim, Sharon J. ; Thompson, Agnieszka K. ; Zubair, Adeel S. ; Otley, Clark C. ; Arpey, Christopher J. ; Baum, Christian ; Roenigk, Randall K. ; Lohse, Christine M. ; Brewer, Jerry D. / Surgical treatment and outcomes of patients with extramammary paget disease : A cohort study. In: Dermatologic Surgery. 2017 ; Vol. 43, No. 5. pp. 708-714.
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abstract = "BACKGROUND Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma occurring mainly in the anogenital region. Traditional management with wide local excision has shown high recurrence rates, thus Mohs micrographic surgery (MMS) has emerged as a promising treatment option. OBJECTIVE To compare long-term outcomes after treatment with MMS or excision for primary EMPD. METHODS AND MATERIALS Retrospective cohort review was conducted for 207 patients with EMPD treated at Mayo Clinic in Rochester, MN, between 1961 and 2012. RESULTS Of the 25 patients treated with MMS, 19 primary tumors were included for outcome analysis, with an estimated 5-year recurrence-free survival rate of 91{\%} (95{\%} confidence interval [CI], 75-100) using Kaplan-Meier curve analysis. Of 158 patients treated with local excision, 124 were included for the analysis, with an estimated 5-year recurrence-free survival rate of 66{\%} (95{\%} CI, 56-78). The hazard ratio (HR) for association of treatment was 0.4 (95{\%} CI, 0.10-1.65; p = .20). Estimated 5-year overall survival rates were 79{\%} for MMS (95{\%} CI, 61-100) and 68{\%} for excision (95{\%} CI, 59-78) (HR, 1.39 [95{\%} CI, 0.69-2.82]; p = .36). CONCLUSION Although treatment of primary EMPD with MMS versus excision did not show statistical difference, MMS demonstrated favorable long-term outcomes and was associated with a higher recurrencefree survival rate.",
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T1 - Surgical treatment and outcomes of patients with extramammary paget disease

T2 - A cohort study

AU - Kim, Sharon J.

AU - Thompson, Agnieszka K.

AU - Zubair, Adeel S.

AU - Otley, Clark C.

AU - Arpey, Christopher J.

AU - Baum, Christian

AU - Roenigk, Randall K.

AU - Lohse, Christine M.

AU - Brewer, Jerry D.

PY - 2017

Y1 - 2017

N2 - BACKGROUND Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma occurring mainly in the anogenital region. Traditional management with wide local excision has shown high recurrence rates, thus Mohs micrographic surgery (MMS) has emerged as a promising treatment option. OBJECTIVE To compare long-term outcomes after treatment with MMS or excision for primary EMPD. METHODS AND MATERIALS Retrospective cohort review was conducted for 207 patients with EMPD treated at Mayo Clinic in Rochester, MN, between 1961 and 2012. RESULTS Of the 25 patients treated with MMS, 19 primary tumors were included for outcome analysis, with an estimated 5-year recurrence-free survival rate of 91% (95% confidence interval [CI], 75-100) using Kaplan-Meier curve analysis. Of 158 patients treated with local excision, 124 were included for the analysis, with an estimated 5-year recurrence-free survival rate of 66% (95% CI, 56-78). The hazard ratio (HR) for association of treatment was 0.4 (95% CI, 0.10-1.65; p = .20). Estimated 5-year overall survival rates were 79% for MMS (95% CI, 61-100) and 68% for excision (95% CI, 59-78) (HR, 1.39 [95% CI, 0.69-2.82]; p = .36). CONCLUSION Although treatment of primary EMPD with MMS versus excision did not show statistical difference, MMS demonstrated favorable long-term outcomes and was associated with a higher recurrencefree survival rate.

AB - BACKGROUND Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma occurring mainly in the anogenital region. Traditional management with wide local excision has shown high recurrence rates, thus Mohs micrographic surgery (MMS) has emerged as a promising treatment option. OBJECTIVE To compare long-term outcomes after treatment with MMS or excision for primary EMPD. METHODS AND MATERIALS Retrospective cohort review was conducted for 207 patients with EMPD treated at Mayo Clinic in Rochester, MN, between 1961 and 2012. RESULTS Of the 25 patients treated with MMS, 19 primary tumors were included for outcome analysis, with an estimated 5-year recurrence-free survival rate of 91% (95% confidence interval [CI], 75-100) using Kaplan-Meier curve analysis. Of 158 patients treated with local excision, 124 were included for the analysis, with an estimated 5-year recurrence-free survival rate of 66% (95% CI, 56-78). The hazard ratio (HR) for association of treatment was 0.4 (95% CI, 0.10-1.65; p = .20). Estimated 5-year overall survival rates were 79% for MMS (95% CI, 61-100) and 68% for excision (95% CI, 59-78) (HR, 1.39 [95% CI, 0.69-2.82]; p = .36). CONCLUSION Although treatment of primary EMPD with MMS versus excision did not show statistical difference, MMS demonstrated favorable long-term outcomes and was associated with a higher recurrencefree survival rate.

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