Surgical resection of high-risk hepatocellular carcinoma: Patient selection, preoperative considerations, and operative technique

Mark J. Truty, Jean Nicolas Vauthey

Research output: Contribution to journalReview article

63 Scopus citations


Hepatocellular carcinoma remains a leading cause of cancer death worldwide. There are an increasing number of patients that do not meet traditional criteria for surgical resection as a result of historically poor outcomes. We define these oncologically high-risk patients as those with either one of these risk factors or a combination of them: Large (>5 cm) primary tumors, multinodular disease, and/or major vascular invasion. With appropriate selection and preparation, long-term survival is possible in this subset of patients after resection. This review focuses on the surgical treatment of these high-risk patients, focusing on our own institution's approach and methods as well as reviewing the literature pertinent to the support of our current practice.

Original languageEnglish (US)
Pages (from-to)1219-1225
Number of pages7
JournalAnnals of surgical oncology
Issue number5
StatePublished - May 1 2010


ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this