TY - JOUR
T1 - Surgical resection of high-risk hepatocellular carcinoma
T2 - Patient selection, preoperative considerations, and operative technique
AU - Truty, Mark J.
AU - Vauthey, Jean Nicolas
N1 - Funding Information:
Acknowledgement: This educational review is part of a series, ‘‘Emerging Therapeutic Approaches to Hepatocellular Carcinoma,’’ which has been supported by an educational grant from Onyx Pharmaceuticals/Bayer Healthcare Pharmaceuticals.
Funding Information:
Author disclosures: Dr. Truty has nothing to disclose. Dr. Vauthey has received grant support from Sanofi-aventis, has participated in the Speakers Bureau of Sanofi-aventis, and has participated in the Speakers Bureau of Genentech.
PY - 2010/5
Y1 - 2010/5
N2 - Hepatocellular carcinoma remains a leading cause of cancer death worldwide. There are an increasing number of patients that do not meet traditional criteria for surgical resection as a result of historically poor outcomes. We define these oncologically high-risk patients as those with either one of these risk factors or a combination of them: Large (>5 cm) primary tumors, multinodular disease, and/or major vascular invasion. With appropriate selection and preparation, long-term survival is possible in this subset of patients after resection. This review focuses on the surgical treatment of these high-risk patients, focusing on our own institution's approach and methods as well as reviewing the literature pertinent to the support of our current practice.
AB - Hepatocellular carcinoma remains a leading cause of cancer death worldwide. There are an increasing number of patients that do not meet traditional criteria for surgical resection as a result of historically poor outcomes. We define these oncologically high-risk patients as those with either one of these risk factors or a combination of them: Large (>5 cm) primary tumors, multinodular disease, and/or major vascular invasion. With appropriate selection and preparation, long-term survival is possible in this subset of patients after resection. This review focuses on the surgical treatment of these high-risk patients, focusing on our own institution's approach and methods as well as reviewing the literature pertinent to the support of our current practice.
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U2 - 10.1245/s10434-010-0976-5
DO - 10.1245/s10434-010-0976-5
M3 - Review article
C2 - 20405326
AN - SCOPUS:77952043363
SN - 1068-9265
VL - 17
SP - 1219
EP - 1225
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 5
ER -