Surgical pathology of the lung in anti-basement membrane antibody-associated Goodpasture's syndrome

Charles M. Lombard, Thomas V. Colby, C. Gregory Elliott

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

We report the findings of lung biopsies from five patients with anti-basement membrane antibody-associated Goodpasture's syndrome (ABMA-GS). In four patients, pulmonary capillaritis with hemorrhage was found on lung biopsy, confirming that pulmonary capillaritis can be found in ABMA-GS. Although alveolar hemorrhage was the dominant pathologic finding in four of our five patients, all five patients had evidence of injury at the level of the alveolar wall, manifested by hyaline membranes and widening of alveolar walls by edematous connective tissue. In one of our patients, alveolar hemorrhage was only focal, and diffuse alveolar damage was the dominant pathologic finding. This pattern of lung disease has not been previously described in ABMA-GS.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalHuman Pathology
Volume20
Issue number5
DOIs
StatePublished - May 1989

Keywords

  • Goodpasture's syndrome
  • adult respiratory distress syndrome
  • alveolitis
  • capillaritis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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