Surgical outcomes for intractable epilepsy in children with epileptic spasms

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14 Scopus citations

Abstract

Epileptic spasms, or seizures marked by flexor, extensor, or flexor-extensor spasms, are not always responsive to medical management. The purpose of our study was to evaluate the outcome of epilepsy surgery in children with medically intractable epileptic spasms. We identified 11 children with epileptic spasms who underwent lesionectomy (36%), lobectomy (27%), multi-lobectomy (9%), hemispherectomy (18%), or corpus callosotomy (9%). At the time of surgery, 6 children had developed other concurrent seizure type(s), including simple partial (9%), complex partial (27%), partial undifferentiated (9%), primary generalized tonic clonic (9%), tonic (9%), atonic (27%), and myoclonic (9%) seizures. Six children (55%) were seizure free at last follow-up from initial surgery. Predictors of favorable outcome included lack of focal slowing and the presence of less than 2 interictal epileptiform abnormalities on postoperative electroencephalogram (P =.035 and.035, respectively). Favorable outcome was significantly associated with parent/caregiver report of improved postoperative developmental outcomes (P =.026).

Original languageEnglish (US)
Pages (from-to)713-720
Number of pages8
JournalJournal of child neurology
Volume27
Issue number6
DOIs
StatePublished - Jun 1 2012

Keywords

  • epilepsy surgery
  • epileptic spasms
  • infantile spasms

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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