Surgical outcome in tuberous sclerosis complex: A multicenter survey

Deepak Madhavan; Sarah Schaffer; Alexei Yankovsky; Alexis Arzimanoglou; Florence Renaldo; Charles M. Zaroff; Josiane LaJoie; Howard L. Weiner; Eva Andermann; David N. Franz; Jennifer Leonard; Mary Connolly; Greg D. Cascino; Orrin Devinsky

doi:10.1111/j.1528-1167.2007.01112.x

Surgical outcome in tuberous sclerosis complex: A multicenter survey

Deepak Madhavan, Sarah Schaffer, Alexei Yankovsky, Alexis Arzimanoglou, Florence Renaldo, Charles M. Zaroff, Josiane LaJoie, Howard L. Weiner, Eva Andermann, David N. Franz, Jennifer Leonard, Mary Connolly, Greg D. Cascino, Orrin Devinsky

Neurology

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Multicenter, retrospective analysis of 70 subjects with TSC following surgery for relief of epilepsy revealed significant associations between younger age at seizure onset, present/prior history of infantile spasms, interictal focality (bilateral versus unilateral), and absence of residual postoperative predominant tuber, and poorer postoperative outcome (p < 0.01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant.

Original language	English (US)
Pages (from-to)	1625-1628
Number of pages	4
Journal	Epilepsia
Volume	48
Issue number	8
DOIs	https://doi.org/10.1111/j.1528-1167.2007.01112.x
State	Published - Aug 2007

Keywords

Outcome
Surgical
Tuberous sclerosis

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1528-1167.2007.01112.x

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title = "Surgical outcome in tuberous sclerosis complex: A multicenter survey",

abstract = "Multicenter, retrospective analysis of 70 subjects with TSC following surgery for relief of epilepsy revealed significant associations between younger age at seizure onset, present/prior history of infantile spasms, interictal focality (bilateral versus unilateral), and absence of residual postoperative predominant tuber, and poorer postoperative outcome (p < 0.01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant.",

keywords = "Outcome, Surgical, Tuberous sclerosis",

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T2 - A multicenter survey

AU - Madhavan, Deepak

AU - Schaffer, Sarah

AU - Yankovsky, Alexei

AU - Arzimanoglou, Alexis

AU - Renaldo, Florence

AU - Zaroff, Charles M.

AU - LaJoie, Josiane

AU - Weiner, Howard L.

AU - Andermann, Eva

AU - Franz, David N.

AU - Leonard, Jennifer

AU - Connolly, Mary

AU - Cascino, Greg D.

AU - Devinsky, Orrin

PY - 2007/8

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AB - Multicenter, retrospective analysis of 70 subjects with TSC following surgery for relief of epilepsy revealed significant associations between younger age at seizure onset, present/prior history of infantile spasms, interictal focality (bilateral versus unilateral), and absence of residual postoperative predominant tuber, and poorer postoperative outcome (p < 0.01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant.

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KW - Tuberous sclerosis

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Surgical outcome in tuberous sclerosis complex: A multicenter survey

Abstract

Keywords

ASJC Scopus subject areas

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