Surgical outcome and predictive factors in adult patients with intractable epilepsy and focal cortical dysplasia

A. M. Siegel, Gregory D Cascino, F. B. Meyer, W. R. Marsh, B. W. Scheithauer, F. W. Sharbrough

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Objectives - To determine the surgical outcome and prognostic factors in adult patients with intractable epilepsy and focal cortical dysplasia (FCD). Materials and methods - We retrospectively studied the operative outcome in 21 consecutive adult patients with FCD who underwent surgical treatment for intractable partial epilepsy. Results - The mean age at surgery was 32.7 years (range, 18-58 years). The median post-operative follow-up was 2.5 years. The FCD was extratemporal in 11 patients, involved the temporal lobe in 10 patients, and was multilobar in eight patients. Eleven patients (52%) were rendered seizure-free, four patients (19%) had >95% reduction in seizures, and two patients (10%) had an 80-94% reduction in seizures. A seizure-free outcome was associated with shorter duration of epilepsy (P = 0.02). Conclusion - Adult patients with FCD may be candidates for surgical treatment of intractable partial epilepsy. Most individuals have neocortical, extrahippocampal seizures and approximately 50% of patients are rendered seizure-free.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalActa Neurologica Scandinavica
Volume113
Issue number2
DOIs
StatePublished - Feb 2006

Fingerprint

Malformations of Cortical Development
Seizures
Partial Epilepsy
Drug Resistant Epilepsy
Temporal Lobe
Epilepsy

Keywords

  • Epilepsy surgery
  • Focal cortical dysplasia
  • Intractable epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Surgical outcome and predictive factors in adult patients with intractable epilepsy and focal cortical dysplasia. / Siegel, A. M.; Cascino, Gregory D; Meyer, F. B.; Marsh, W. R.; Scheithauer, B. W.; Sharbrough, F. W.

In: Acta Neurologica Scandinavica, Vol. 113, No. 2, 02.2006, p. 65-71.

Research output: Contribution to journalArticle

Siegel, A. M. ; Cascino, Gregory D ; Meyer, F. B. ; Marsh, W. R. ; Scheithauer, B. W. ; Sharbrough, F. W. / Surgical outcome and predictive factors in adult patients with intractable epilepsy and focal cortical dysplasia. In: Acta Neurologica Scandinavica. 2006 ; Vol. 113, No. 2. pp. 65-71.
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