Surgical margins in head and neck cancer

A contemporary review

Michael L. Hinni, Alfio Ferlito, Margaret S. Brandwein-Gensler, Robert P. Takes, Carl E. Silver, William H. Westra, Raja R. Seethala, Juan P. Rodrigo, June Corry, Carol R. Bradford, Jennifer L. Hunt, Primož Strojan, Kenneth O. Devaney, Douglas R. Gnepp, Dana M. Hartl, Luiz P. Kowalski, Alessandra Rinaldo, Leon Barnes

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Adequate resection margins are critical to the treatment decisions and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). However, there are numerous controversies regarding reporting and interpretation of the status of resection margins. Fundamental issues relating to the basic definition of margin adequacy, uniform reporting standards for margins, optimal method of specimen dissection, and the role of intraoperative frozen section evaluation, all require further clarification and standardization. Future horizons for margin surveillance offer the possible use of novel methods such as "molecular margins" and contact microscopic endoscopy, However, the limitations of these approaches need to be understood. The goal of this review was to evaluate these issues to define a more rational, standardized approach for achieving resection margin adequacy for patients with HNSCC undergoing curative resection.

Original languageEnglish (US)
Pages (from-to)1362-1370
Number of pages9
JournalHead and Neck
Volume35
Issue number9
DOIs
StatePublished - Sep 2013

Fingerprint

Head and Neck Neoplasms
Frozen Sections
Endoscopy
Dissection
Margins of Excision
Carcinoma, squamous cell of head and neck
Therapeutics

Keywords

  • frozen section
  • head neck cancer
  • molecular factors
  • pattern of invasion
  • surgical margins

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Hinni, M. L., Ferlito, A., Brandwein-Gensler, M. S., Takes, R. P., Silver, C. E., Westra, W. H., ... Barnes, L. (2013). Surgical margins in head and neck cancer: A contemporary review. Head and Neck, 35(9), 1362-1370. https://doi.org/10.1002/hed.23110

Surgical margins in head and neck cancer : A contemporary review. / Hinni, Michael L.; Ferlito, Alfio; Brandwein-Gensler, Margaret S.; Takes, Robert P.; Silver, Carl E.; Westra, William H.; Seethala, Raja R.; Rodrigo, Juan P.; Corry, June; Bradford, Carol R.; Hunt, Jennifer L.; Strojan, Primož; Devaney, Kenneth O.; Gnepp, Douglas R.; Hartl, Dana M.; Kowalski, Luiz P.; Rinaldo, Alessandra; Barnes, Leon.

In: Head and Neck, Vol. 35, No. 9, 09.2013, p. 1362-1370.

Research output: Contribution to journalArticle

Hinni, ML, Ferlito, A, Brandwein-Gensler, MS, Takes, RP, Silver, CE, Westra, WH, Seethala, RR, Rodrigo, JP, Corry, J, Bradford, CR, Hunt, JL, Strojan, P, Devaney, KO, Gnepp, DR, Hartl, DM, Kowalski, LP, Rinaldo, A & Barnes, L 2013, 'Surgical margins in head and neck cancer: A contemporary review', Head and Neck, vol. 35, no. 9, pp. 1362-1370. https://doi.org/10.1002/hed.23110
Hinni ML, Ferlito A, Brandwein-Gensler MS, Takes RP, Silver CE, Westra WH et al. Surgical margins in head and neck cancer: A contemporary review. Head and Neck. 2013 Sep;35(9):1362-1370. https://doi.org/10.1002/hed.23110
Hinni, Michael L. ; Ferlito, Alfio ; Brandwein-Gensler, Margaret S. ; Takes, Robert P. ; Silver, Carl E. ; Westra, William H. ; Seethala, Raja R. ; Rodrigo, Juan P. ; Corry, June ; Bradford, Carol R. ; Hunt, Jennifer L. ; Strojan, Primož ; Devaney, Kenneth O. ; Gnepp, Douglas R. ; Hartl, Dana M. ; Kowalski, Luiz P. ; Rinaldo, Alessandra ; Barnes, Leon. / Surgical margins in head and neck cancer : A contemporary review. In: Head and Neck. 2013 ; Vol. 35, No. 9. pp. 1362-1370.
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