TY - CHAP
T1 - Surgical management of the clinically negative and locally advanced inguinal region in patients with squamous penile cancer
AU - Pettaway, Curtis
AU - Pagliaro, Lance
N1 - Publisher Copyright:
© Springer Science+Business Media New York 2014. All rights are reserved.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The presence and extent of metastasis to the inguinal region are the most important prognostic factors for survival among patients with squamous penile cancer. These findings affect the prognosis of the disease more than tumor grade, gross appearance, and morphologic or microscopic patterns of the primary tumor. Unlike many other genitourinary tumors, which mandate systemic therapeutic strategies once metastasis has occurred, lymphadenectomy alone can be curative and should be performed. The biology of squamous penile cancer is such that it exhibits a prolonged locoregional phase before distant dissemination, providing a rationale for the therapeutic value of lymphadenectomy. However, owing to the morbidity of traditional lymphadenectomy, especially among those patients with a clinically negative groin, contemporary controversial issues include (1) the selection of patients for lymphadenectomy vs. careful observation, (2) the types of procedures to correctly stage the inguinal region with low morbidity, and (3) multimodal strategies to improve survival among patients with bulky inguinal metastases. In this chapter, we will focus on the surgical evaluation and management of the inguinal region among penile cancer patients with either no palpable adenopathy or those with suspected or proven advanced regional metastases.
AB - The presence and extent of metastasis to the inguinal region are the most important prognostic factors for survival among patients with squamous penile cancer. These findings affect the prognosis of the disease more than tumor grade, gross appearance, and morphologic or microscopic patterns of the primary tumor. Unlike many other genitourinary tumors, which mandate systemic therapeutic strategies once metastasis has occurred, lymphadenectomy alone can be curative and should be performed. The biology of squamous penile cancer is such that it exhibits a prolonged locoregional phase before distant dissemination, providing a rationale for the therapeutic value of lymphadenectomy. However, owing to the morbidity of traditional lymphadenectomy, especially among those patients with a clinically negative groin, contemporary controversial issues include (1) the selection of patients for lymphadenectomy vs. careful observation, (2) the types of procedures to correctly stage the inguinal region with low morbidity, and (3) multimodal strategies to improve survival among patients with bulky inguinal metastases. In this chapter, we will focus on the surgical evaluation and management of the inguinal region among penile cancer patients with either no palpable adenopathy or those with suspected or proven advanced regional metastases.
UR - http://www.scopus.com/inward/record.url?scp=84929878647&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929878647&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-0461-7_10
DO - 10.1007/978-1-4939-0461-7_10
M3 - Chapter
AN - SCOPUS:84929878647
SN - 1493904604
SN - 9781493904600
SP - 153
EP - 171
BT - Management of Penile Cancer
PB - Springer New York
ER -