Surgery for vena caval tumor extension in renal cancer

Stephen A. Boorjian, Michael L. Blute

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: We review recent efforts designed to improve the preoperative assessment, minimize the surgical morbidity, and develop multimodal treatments for patient with renal cell carcinoma and venous tumor thrombus. RECENT FINDINGS: The ability of computerized tomography to classify venous thrombus has improved with recent advancements in multidetector/three- dimensional technology. The utility of preoperative imaging to predict vascular wall invasion, which carries adverse prognostic significance, has also been demonstrated. Minimally invasive approaches to low-level thrombus cases have been explored, whereas techniques to minimize the morbidity associated with the use of cardiopulmonary bypass and circulatory arrest in patients with a retrohepatic or supradiaphragmatic thrombus, including antegrade cerebral perfusion, the use of cardiopulmonary bypass with mild hypothermia, and the increased application of veno-venous bypass, have improved perioperative outcomes. Meanwhile, results from several case reports suggest a potential role for neoadjuvant systemic therapy with tyrosine kinase inhibitors prior to resection. SUMMARY: Improvements in perioperative assessment and surgical technique have decreased the morbidity and improved the outcomes for patients with renal cell carcinoma and venous tumor thrombus. Further investigations of the role for targeted therapies in the management of these complex patients are needed to define the optimal multimodal approach.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalCurrent Opinion in Urology
Volume19
Issue number5
DOIs
StatePublished - Sep 2009
Externally publishedYes

Fingerprint

Venae Cavae
Kidney Neoplasms
Thrombosis
Neoplasms
Morbidity
Cardiopulmonary Bypass
Renal Cell Carcinoma
Combined Modality Therapy
Neoadjuvant Therapy
Hypothermia
Protein-Tyrosine Kinases
Blood Vessels
Perfusion
Tomography
Technology

Keywords

  • Kidney
  • Nephrectomy
  • Renal cell carcinoma
  • Venous tumor thrombus

ASJC Scopus subject areas

  • Urology

Cite this

Surgery for vena caval tumor extension in renal cancer. / Boorjian, Stephen A.; Blute, Michael L.

In: Current Opinion in Urology, Vol. 19, No. 5, 09.2009, p. 473-477.

Research output: Contribution to journalArticle

Boorjian, Stephen A. ; Blute, Michael L. / Surgery for vena caval tumor extension in renal cancer. In: Current Opinion in Urology. 2009 ; Vol. 19, No. 5. pp. 473-477.
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