Supraspinal electrophysiological models for studying chronic pain

Long Jun Wu, Min Zhuo

Research output: Contribution to journalReview article

Abstract

Electrophysiology has been intensively used in studying molecular mechanisms of pain transmission, modulation and plasticity. In vitro slice recordings provided detailed information on synaptic transmission and plasticity under both physiological and pathological pain conditions. In vivo recordings integrate the information of functional activities in the nociceptive pathway. Combination of electrophysiology with genetically manipulated mice, new behavioral models, in vivo/in vitro imaging and molecular biology will identify new molecular targets for controlling chronic pain in the future.

Original languageEnglish (US)
Pages (from-to)405-411
Number of pages7
JournalDrug Discovery Today: Disease Models
Volume3
Issue number4
DOIs
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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