Suppressive and enhancing T cell factors as I region gene products: properties and the subregion assignment Origins of Lymphocyte Diversity

T. Tada, M. Taniguchi, C. S. David

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Two distinct antigen-specific T-cell factors having opposite functions in the regulation of antibody response are described, one suppressive and the other enhancing for a T-cell-dependent antibody response. Both factors are found to have I-region gene expressions. Available evidence indicates that they are coded for by genes present in distinct I subregions, and that the targets for these factors are probably T cells also carrying I-region determinants. Incorporating the new target cell type in the network of immunocompetent cell interactions, possible mechanisms of T-cell mediated regulation of antibody response are discussed.

Original languageEnglish (US)
Pages (from-to)119-127
Number of pages9
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume41
Issue number1
StatePublished - 1976
Externally publishedYes

Fingerprint

Immunologic Suppressor Factors
TCF Transcription Factors
Lymphocytes
Antibody Formation
lymphocytes
T-cells
T-lymphocytes
Genes
Antibodies
antibodies
T-Lymphocytes
genes
Gene expression
Cell Communication
Gene Expression
antigens
gene expression
cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Molecular Biology

Cite this

Suppressive and enhancing T cell factors as I region gene products : properties and the subregion assignment Origins of Lymphocyte Diversity. / Tada, T.; Taniguchi, M.; David, C. S.

In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. 41, No. 1, 1976, p. 119-127.

Research output: Contribution to journalArticle

@article{a0742db5d15f4729a71ee59b38ecbf4b,
title = "Suppressive and enhancing T cell factors as I region gene products: properties and the subregion assignment Origins of Lymphocyte Diversity",
abstract = "Two distinct antigen-specific T-cell factors having opposite functions in the regulation of antibody response are described, one suppressive and the other enhancing for a T-cell-dependent antibody response. Both factors are found to have I-region gene expressions. Available evidence indicates that they are coded for by genes present in distinct I subregions, and that the targets for these factors are probably T cells also carrying I-region determinants. Incorporating the new target cell type in the network of immunocompetent cell interactions, possible mechanisms of T-cell mediated regulation of antibody response are discussed.",
author = "T. Tada and M. Taniguchi and David, {C. S.}",
year = "1976",
language = "English (US)",
volume = "41",
pages = "119--127",
journal = "Cold Spring Harbor Symposia on Quantitative Biology",
issn = "0091-7451",
publisher = "Cold Spring Harbor Laboratory Press",
number = "1",

}

TY - JOUR

T1 - Suppressive and enhancing T cell factors as I region gene products

T2 - properties and the subregion assignment Origins of Lymphocyte Diversity

AU - Tada, T.

AU - Taniguchi, M.

AU - David, C. S.

PY - 1976

Y1 - 1976

N2 - Two distinct antigen-specific T-cell factors having opposite functions in the regulation of antibody response are described, one suppressive and the other enhancing for a T-cell-dependent antibody response. Both factors are found to have I-region gene expressions. Available evidence indicates that they are coded for by genes present in distinct I subregions, and that the targets for these factors are probably T cells also carrying I-region determinants. Incorporating the new target cell type in the network of immunocompetent cell interactions, possible mechanisms of T-cell mediated regulation of antibody response are discussed.

AB - Two distinct antigen-specific T-cell factors having opposite functions in the regulation of antibody response are described, one suppressive and the other enhancing for a T-cell-dependent antibody response. Both factors are found to have I-region gene expressions. Available evidence indicates that they are coded for by genes present in distinct I subregions, and that the targets for these factors are probably T cells also carrying I-region determinants. Incorporating the new target cell type in the network of immunocompetent cell interactions, possible mechanisms of T-cell mediated regulation of antibody response are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0017204474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017204474&partnerID=8YFLogxK

M3 - Article

C2 - 302186

AN - SCOPUS:0017204474

VL - 41

SP - 119

EP - 127

JO - Cold Spring Harbor Symposia on Quantitative Biology

JF - Cold Spring Harbor Symposia on Quantitative Biology

SN - 0091-7451

IS - 1

ER -