Suppressive and enhancing T cell factors as I region gene products: properties and the subregion assignment Origins of Lymphocyte Diversity

T. Tada, M. Taniguchi, C. S. David

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Two distinct antigen-specific T-cell factors having opposite functions in the regulation of antibody response are described, one suppressive and the other enhancing for a T-cell-dependent antibody response. Both factors are found to have I-region gene expressions. Available evidence indicates that they are coded for by genes present in distinct I subregions, and that the targets for these factors are probably T cells also carrying I-region determinants. Incorporating the new target cell type in the network of immunocompetent cell interactions, possible mechanisms of T-cell mediated regulation of antibody response are discussed.

Original languageEnglish (US)
Pages (from-to)119-127
Number of pages9
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume41
Issue number1
DOIs
StatePublished - Jan 1 1976

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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