Suppression of mitogen- and antigen-induced lymphocyte proliferation by lanthanides

M. Yamage, C. H. Evans

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Lanthanide ions (Ln3+) inhibited the proliferative response of human lymphocytes to various polyclonal mitogens and the 'purified protein derivative' (PPD) of the tuberculin antigen. Of the four Ln3+ ions tested lanthanum (La3+) was the strongest inhibitor; erbium (Er3+) and lutetium (Lu3+) were only weakly active, while samarium (Sm3+) had intermediate potency. At a concentration of 1 mM, La3+ almost completely inhibited the uptake of [3H]-thymidine by lymphocytes exposed to mitogenic agents. Trypan blue exclusion tests confirmed that the La3+ ions were not toxic. These findings may bear upon the reported anti-inflammatory properties of the lanthanides.

Original languageEnglish (US)
Pages (from-to)1129-1131
Number of pages3
JournalExperientia
Volume45
Issue number11-12
DOIs
StatePublished - Dec 1 1989

Keywords

  • Lanthanide
  • cell division
  • inflammation
  • lymphocyte

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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