Suppression of mitogen- and antigen-induced lymphocyte proliferation by lanthanides

M. Yamage; C. H. Evans

doi:10.1007/BF01950178

Suppression of mitogen- and antigen-induced lymphocyte proliferation by lanthanides

M. Yamage, C. H. Evans

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Lanthanide ions (Ln³⁺) inhibited the proliferative response of human lymphocytes to various polyclonal mitogens and the 'purified protein derivative' (PPD) of the tuberculin antigen. Of the four Ln³⁺ ions tested lanthanum (La³⁺) was the strongest inhibitor; erbium (Er³⁺) and lutetium (Lu³⁺) were only weakly active, while samarium (Sm³⁺) had intermediate potency. At a concentration of 1 mM, La³⁺ almost completely inhibited the uptake of [³H]-thymidine by lymphocytes exposed to mitogenic agents. Trypan blue exclusion tests confirmed that the La³⁺ ions were not toxic. These findings may bear upon the reported anti-inflammatory properties of the lanthanides.

Original language	English (US)
Pages (from-to)	1129-1131
Number of pages	3
Journal	Experientia
Volume	45
Issue number	11-12
DOIs	https://doi.org/10.1007/BF01950178
State	Published - Dec 1989

Keywords

Lanthanide
cell division
inflammation
lymphocyte

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/BF01950178

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abstract = "Lanthanide ions (Ln3+) inhibited the proliferative response of human lymphocytes to various polyclonal mitogens and the 'purified protein derivative' (PPD) of the tuberculin antigen. Of the four Ln3+ ions tested lanthanum (La3+) was the strongest inhibitor; erbium (Er3+) and lutetium (Lu3+) were only weakly active, while samarium (Sm3+) had intermediate potency. At a concentration of 1 mM, La3+ almost completely inhibited the uptake of [3H]-thymidine by lymphocytes exposed to mitogenic agents. Trypan blue exclusion tests confirmed that the La3+ ions were not toxic. These findings may bear upon the reported anti-inflammatory properties of the lanthanides.",

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AU - Evans, C. H.

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N2 - Lanthanide ions (Ln3+) inhibited the proliferative response of human lymphocytes to various polyclonal mitogens and the 'purified protein derivative' (PPD) of the tuberculin antigen. Of the four Ln3+ ions tested lanthanum (La3+) was the strongest inhibitor; erbium (Er3+) and lutetium (Lu3+) were only weakly active, while samarium (Sm3+) had intermediate potency. At a concentration of 1 mM, La3+ almost completely inhibited the uptake of [3H]-thymidine by lymphocytes exposed to mitogenic agents. Trypan blue exclusion tests confirmed that the La3+ ions were not toxic. These findings may bear upon the reported anti-inflammatory properties of the lanthanides.

AB - Lanthanide ions (Ln3+) inhibited the proliferative response of human lymphocytes to various polyclonal mitogens and the 'purified protein derivative' (PPD) of the tuberculin antigen. Of the four Ln3+ ions tested lanthanum (La3+) was the strongest inhibitor; erbium (Er3+) and lutetium (Lu3+) were only weakly active, while samarium (Sm3+) had intermediate potency. At a concentration of 1 mM, La3+ almost completely inhibited the uptake of [3H]-thymidine by lymphocytes exposed to mitogenic agents. Trypan blue exclusion tests confirmed that the La3+ ions were not toxic. These findings may bear upon the reported anti-inflammatory properties of the lanthanides.

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KW - cell division

KW - inflammation

KW - lymphocyte

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Suppression of mitogen- and antigen-induced lymphocyte proliferation by lanthanides

Abstract

Keywords

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