Suppression of frequent premature ventricular contractions and improvement of left ventricular function in patients with presumed idiopathic dilated cardiomyopathy

Douglas F. Duffee, Win Kuang Shen, Hugh C. Smith

Research output: Contribution to journalArticle

130 Scopus citations

Abstract

• Objective: To examine the hypothesis that suppression of frequent premature ventricular contractions may be associated with improvement in left ventricular function in patients with presumed idiopathic dilated cardiomyopathy. • Design: We conducted a retrospective case study and statistical analysis of the effect of cardiac medical therapy on outcome. • Material and Methods: The study population consisted of 14 patients with more than 20,000 premature ventricular contractions in 24 hours recorded by Holter monitoring and associated left ventricular dysfunction (ejection fraction, 40% or less). Clinical characteristics, number of premature ventricular contractions per hour on 24-hour ambulatory Holter monitoring, and ejection fraction based on transthoracic echocardiography were compared before and after cardiac therapeutic intervention. • Results: Of the 14 patients, 10 had presumed idiopathic dilated cardiomyopathy, and 4 had ischémie heart disease. Of the overall study group, seven had received additional cardiac medical therapy after the index evaluation, including four patients who had amiodarone therapy. A significant reduction (75% or more from baseline) in premature ventricular contractions after medical therapeutic intervention was observed in five patients at the first follow-up examination. The mean interval to the first follow-up examination was 6 ±3 months. Of the five patients, four had significant improvement in clinical functional status and the ejection fraction. The mean ejection fraction of these five patients increased from 27 ±10% at baseline to 49 ±17% after medical therapy (P = 0.04). • Conclusion: The suppression of frequent premature ventricular contractions may be associated with improvement of left ventricular function in patients with presumed idiopathic dilated cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)430-433
Number of pages4
JournalMayo Clinic proceedings
Volume73
Issue number5
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Medicine(all)

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